Evidence map›Paper›PMID 35464466›Full record

ArticleFrontiers in immunology2022

Regulation of Proinflammatory Molecules and Tissue Factor by SARS-CoV-2 Spike Protein in Human Placental Cells: Implications for SARS-CoV-2 Pathogenesis in Pregnant Women.

Xiaofang Guo, Nihan Semerci, Viviana De Assis, Umit A Kayisli, Frederick Schatz, Thora S Steffensen, Ozlem Guzeloglu-Kayisli, Charles J Lockwood

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 25 citations in OpenAlex.

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  11. COVID-19 and pregnancy: clinical outcomes; mechanisms, and vaccine efficacy.Translational research : the journal of laboratory and clinical medicine · 2023
    Review
  12. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Xiaofang GuoDepartment of Obstetrics and Gynecology, University of South Florida, Morsani College of Medicine, Tampa, FL, United States.
Nihan SemerciDepartment of Obstetrics and Gynecology, University of South Florida, Morsani College of Medicine, Tampa, FL, United States.
Viviana De AssisDepartment of Obstetrics and Gynecology, University of South Florida, Morsani College of Medicine, Tampa, FL, United States.
Umit A KayisliDepartment of Obstetrics and Gynecology, University of South Florida, Morsani College of Medicine, Tampa, FL, United States.
Frederick SchatzDepartment of Obstetrics and Gynecology, University of South Florida, Morsani College of Medicine, Tampa, FL, United States.
Thora S SteffensenDepartment of Pathology, Tampa General Hospital, Tampa, FL, United States.
Ozlem Guzeloglu-KayisliDepartment of Obstetrics and Gynecology, University of South Florida, Morsani College of Medicine, Tampa, FL, United States.
Charles J LockwoodDepartment of Obstetrics and Gynecology, University of South Florida, Morsani College of Medicine, Tampa, FL, United States.
University of South Florida · USTampa General Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

SARS-CoV-2 infects cells

Indexed as

COVID-19Placenta DiseasesPregnancy Complications, InfectiousAngiotensin-Converting Enzyme 2Cell Line, TumorCytokinesEndothelial CellsFemaleHumansPlacentaPregnancyPregnant PeopleSARS-CoV-2Spike Glycoprotein, CoronavirusThromboplastinAngiotensin-Converting Enzyme 2CytokinesF3 protein, humanSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2ThromboplastinACE2pregnancyproinflammatory cytokinesSARS-CoV-2tissue factorTMPRSS2trophoblast

Identifiers

PMID35464466
PMCPMC9022221
OpenAlexW4226224605

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.