Evidence map›Paper›PMID 35464447›Full record

ArticleFrontiers in immunology2022

The Long Non-Coding RNA Nostrill Regulates Transcription of Irf7 Through Interaction With NF-κB p65 to Enhance Intestinal Epithelial Defense Against

Nicholas W Mathy, Silu Deng, Ai-Yu Gong, Min Li, Yang Wang, Olivia Burleigh, Andrew Kochvar, Erin R Whiteford, Annemarie Shibata, Xian-Ming Chen

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 22 citations in OpenAlex.

  1. Use of ncRNAs to Study Host Cell-Parasite Interactions.Methods in molecular biology (Clifton, N.J.) · 2026
    Article
  2. Article
  3. Article
  4. LncRNA BACE1-AS delays the propagation ofMicrobiology spectrum · 2025
    Article
  5. Microbiology spectrum · 2025
    Article
  6. Review
  7. Review
  8. Article
  9. Unveiling the Hidden Regulators: The Impact of lncRNAs on Zoonoses.International journal of molecular sciences · 2024
    Review
  10. Article
  11. Frontiers in immunology · 2024
    Article
  12. Article
  13. Review
  14. Review
  15. Early immune and host cell responses toFrontiers in parasitology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Nicholas W MathyDepartment of Medical Microbiology and Immunology, Creighton University School of Medicine, Omaha, NE, United States.
Silu DengDepartment of Medical Microbiology and Immunology, Creighton University School of Medicine, Omaha, NE, United States.
Ai-Yu GongDepartment of Medical Microbiology and Immunology, Creighton University School of Medicine, Omaha, NE, United States.
Min LiDepartment of Medical Microbiology and Immunology, Creighton University School of Medicine, Omaha, NE, United States.
Yang WangDepartment of Medical Microbiology and Immunology, Creighton University School of Medicine, Omaha, NE, United States.
Olivia BurleighDepartment of Biology, Creighton University, Omaha, NE, United States.
Andrew KochvarDepartment of Biology, Creighton University, Omaha, NE, United States.
Erin R WhitefordCreighton University, School of Medicine, Omaha, NE, United States.
Annemarie ShibataDepartment of Biology, Creighton University, Omaha, NE, United States.
Xian-Ming ChenDepartment of Medical Microbiology and Immunology, Creighton University School of Medicine, Omaha, NE, United States.
Creighton University · USRush University Medical Center · US

Funding

UNMC Structural Biology CoreP20GM103427 · NIGMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI PAUL L SORGEN · 2012 to 2026
$59.2M
Understanding the progression of hearing loss in an endolymphatic hydrops modelP20GM139762 · NIGMS · CREIGHTON UNIVERSITY · PI Hui Hong · 2021 to 2026
$16.1M
Molecular Basis of Intestinal CryptosporidiosisR01AI116323 · NIAID · RUSH UNIVERSITY MEDICAL CENTER · PI CHEN, XIAN-MING · 2015 to 2025
$4.2M
LincRNAs in Mucosal Defense to AIDS Opportunistic Pathogen CryptosporidiumR01AI136877 · NIAID · RUSH UNIVERSITY MEDICAL CENTER · PI CHEN, XIAN-MING · 2018 to 2022
$1.9M
Regulation of the Microglial Neuroimmune Response by Long Non-Coding RNAsR15AI156879 · NIAID · CREIGHTON UNIVERSITY · PI Annemarie Shibata · 2022 to 2026
$986k
LncRNA regulation of Type I IFN signaling in intestinal epitheliumR21AI156370 · NIAID · RUSH UNIVERSITY MEDICAL CENTER · PI CHEN, XIAN-MING · 2021 to 2022
$432k
Intestinal Stem Cell Responses to Cryptosporidium InfectionR21AI141325 · NIAID · RUSH UNIVERSITY MEDICAL CENTER · PI CHEN, XIAN-MING · 2020 to 2021
$415k
NIAID NIH HHS R01 AI116323NIAID NIH HHS R01 AI136877NIAID NIH HHS R15 AI156879NIAID NIH HHS R21 AI141325NIAID NIH HHS R21 AI156370NIGMS NIH HHS P20 GM103427NIGMS NIH HHS P20 GM139762
6 · The paper itself

Abstract

The cells of the intestinal epithelium establish the frontline for host defense against pathogens in the gastrointestinal tract and play a vital role in the initiation of the immune response. Increasing evidence supports the role of long non-coding RNAs (lncRNAs) as critical regulators of diverse cellular processes, however, their role in antimicrobial host defense is incompletely understood. In this study, we provide evidence that the lncRNA Nostrill is upregulated in the intestinal epithelium following infection by

Indexed as

Anti-Infective AgentsCryptosporidiosisCryptosporidiumCryptosporidium parvumRNA, Long NoncodingHumansNF-kappa BAnti-Infective AgentsNF-kappa BRNA, Long Noncoding2500002B13RikCryptosporidiumintestinal epithelial cellsIRF7long non-coding RNANF-κBNostrillNR_126553

Identifiers

PMID35464447
PMCPMC9021721
OpenAlexW4226090511

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.