Evidence map›Paper›PMID 35464442›Full record

ArticleFrontiers in immunology2022

Genetic Engineering and Enrichment of Human NK Cells for CAR-Enhanced Immunotherapy of Hematological Malignancies.

Maren Soldierer, Arthur Bister, Corinna Haist, Aniththa Thivakaran, Sevgi Can Cengiz, Stephanie Sendker, Nina Bartels, Antonia Thomitzek, Denise Smorra, Maryam Hejazi and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
4.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 45 citations in OpenAlex.

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  9. Targets for CAR Therapy in Multiple Myeloma.International journal of molecular sciences · 2025
    Review
  10. Cell therapy in pediatric blood diseases.Frontiers in medicine · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 3 institutions in 1 country.

Maren SoldiererDepartment of Pediatrics III, University Children's Hospital Essen, University Duisburg-Essen, Essen, Germany.
Arthur BisterDepartment of Pediatrics III, University Children's Hospital Essen, University Duisburg-Essen, Essen, Germany.
Corinna HaistDepartment of Pediatrics III, University Children's Hospital Essen, University Duisburg-Essen, Essen, Germany.
Aniththa ThivakaranDepartment of Pediatrics III, University Children's Hospital Essen, University Duisburg-Essen, Essen, Germany.
Sevgi Can CengizDepartment of Pediatrics III, University Children's Hospital Essen, University Duisburg-Essen, Essen, Germany.
Stephanie SendkerDepartment of Pediatrics III, University Children's Hospital Essen, University Duisburg-Essen, Essen, Germany.
Nina BartelsDepartment of Experimental Medical Physics, Heinrich Heine University, Düsseldorf, Germany.
Antonia ThomitzekDepartment of Otorhinolaryngology, Head & Neck Surgery, University Hospital Düsseldorf, Heinrich Heine University, Düsseldorf, Germany.
Denise SmorraDepartment of Pediatrics III, University Children's Hospital Essen, University Duisburg-Essen, Essen, Germany.
Maryam HejaziInstitute for Transplantation Diagnostics and Cell Therapeutics, Heinrich-Heine University, Düsseldorf, Germany.
Markus UhrbergInstitute for Transplantation Diagnostics and Cell Therapeutics, Heinrich-Heine University, Düsseldorf, Germany.
Kathrin ScheckenbachDepartment of Otorhinolaryngology, Head & Neck Surgery, University Hospital Düsseldorf, Heinrich Heine University, Düsseldorf, Germany.
Cornelia MonzelDepartment of Experimental Medical Physics, Heinrich Heine University, Düsseldorf, Germany.
Constanze WiekDepartment of Otorhinolaryngology, Head & Neck Surgery, University Hospital Düsseldorf, Heinrich Heine University, Düsseldorf, Germany.
Dirk ReinhardtDepartment of Pediatrics III, University Children's Hospital Essen, University Duisburg-Essen, Essen, Germany.
Naghmeh NiktorehDepartment of Pediatrics III, University Children's Hospital Essen, University Duisburg-Essen, Essen, Germany.
Helmut HanenbergDepartment of Pediatrics III, University Children's Hospital Essen, University Duisburg-Essen, Essen, Germany.
Heinrich Heine University Düsseldorf · DEUniversity of Duisburg-Essen · DEDüsseldorf University Hospital · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The great clinical success of chimeric antigen receptor (CAR) T cells has unlocked new levels of immunotherapy for hematological malignancies. Genetically modifying natural killer (NK) cells as alternative CAR immune effector cells is also highly promising, as NK cells can be transplanted across HLA barriers without causing graft-versus-host disease. Therefore,

Indexed as

Hematologic NeoplasmsLeukemia, Myeloid, AcutePrecursor Cell Lymphoblastic Leukemia-LymphomaAnimalsCell Line, TumorGenetic EngineeringHumansImmunotherapy, AdoptiveKiller Cells, NaturalMiceMice, Inbred NODMice, SCIDadoptive cellular immunotherapychimeric antigen receptorgenetic engineeringhuman NK cellslentiviral vectors (LVS)transduction

Identifiers

PMID35464442
PMCPMC9022481
OpenAlexW4225739192

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.