Evidence map›Paper›PMID 35464415›Full record

ArticleFrontiers in immunology2022

Screening and Identification of HBV Epitopes Restricted by Multiple Prevalent HLA-A Allotypes.

Yan Ding, Zining Zhou, Xingyu Li, Chen Zhao, Xiaoxiao Jin, Xiaotao Liu, Yandan Wu, Xueyin Mei, Jian Li, Jie Qiu and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Yan DingDepartment of Microbiology and Immunology, Medical School, Southeast University, Nanjing, China.
Zining ZhouDepartment of Microbiology and Immunology, Medical School, Southeast University, Nanjing, China.
Xingyu LiKey Laboratory of Developmental Genes and Human Disease, Ministry of Education, School of Life Science and Technology, Southeast University, Nanjing, China.
Chen ZhaoDepartment of Microbiology and Immunology, Medical School, Southeast University, Nanjing, China.
Xiaoxiao JinDepartment of Microbiology and Immunology, Medical School, Southeast University, Nanjing, China.
Xiaotao LiuDepartment of Microbiology and Immunology, Medical School, Southeast University, Nanjing, China.
Yandan WuDepartment of Microbiology and Immunology, Medical School, Southeast University, Nanjing, China.
Xueyin MeiKey Laboratory of Developmental Genes and Human Disease, Ministry of Education, School of Life Science and Technology, Southeast University, Nanjing, China.
Jian LiKey Laboratory of Developmental Genes and Human Disease, Ministry of Education, School of Life Science and Technology, Southeast University, Nanjing, China.
Jie QiuDivision of Hepatitis, Nanjing Second Hospital, Nanjing Hospital Affiliated to Nanjing University of Chinese Medicine, Nanjing, China.
Chuanlai ShenDepartment of Microbiology and Immunology, Medical School, Southeast University, Nanjing, China.
Southeast University · CNNanjing University of Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although host T cell immune responses to hepatitis B virus (HBV) have been demonstrated to have important influences on the outcome of HBV infection, the development of T cell epitope-based vaccine and T cell therapy and the clinical evaluation of specific T cell function are currently hampered markedly by the lack of validated HBV T cell epitopes covering broad patients. This study aimed to screen T cell epitopes spanning overall HBsAg, HBeAg, HBx and HBpol proteins and presenting by thirteen prevalent human leukocyte antigen (HLA)-A allotypes which gather a total gene frequency of around 95% in China and Northeast Asia populations. 187 epitopes were

Indexed as

Hepatitis BHepatitis B virusEpitopes, T-LymphocyteHepatitis B Surface AntigensHLA-A AntigensHumansInterferon-gammaLeukocytes, MononuclearPeptidesEpitopes, T-LymphocyteHepatitis B Surface AntigensHLA-A AntigensInterferon-gammaPeptidesantigen-specific T cell detectionbioinformatics analysisELISPOThepatitis B virusHLA-AT cell epitope

Identifiers

PMID35464415
PMCPMC9021956
OpenAlexW4225344778

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.