Evidence map›Paper›PMID 35464310›Full record

ArticleFrontiers in neuroscience2022

Loss of Function of the Neural Cell Adhesion Molecule NrCAM Regulates Differentiation, Proliferation and Neurogenesis in Early Postnatal Hypothalamic Tanycytes.

Alex Moore, Kavitha Chinnaiya, Dong Won Kim, Sarah Brown, Iain Stewart, Sarah Robins, Georgina K C Dowsett, Charlotte Muir, Marco Travaglio, Jo E Lewis and 4 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 2 countries.

Alex MooreSchool of Biosciences, The University of Sheffield, Sheffield, United Kingdom.
Kavitha ChinnaiyaSchool of Biosciences, The University of Sheffield, Sheffield, United Kingdom.
Dong Won KimSolomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Sarah BrownSchool of Biosciences, The University of Sheffield, Sheffield, United Kingdom.
Iain StewartSchool of Biosciences, The University of Sheffield, Sheffield, United Kingdom.
Sarah RobinsSchool of Biosciences, The University of Sheffield, Sheffield, United Kingdom.
Georgina K C DowsettWellcome Trust-Medical Research Council Institute of Metabolic Science-Metabolic Research Laboratories, University of Cambridge, Cambridge, United Kingdom.
Charlotte MuirSchool of Life Sciences, University of Nottingham, Nottingham, United Kingdom.
Marco TravaglioSchool of Life Sciences, University of Nottingham, Nottingham, United Kingdom.
Jo E LewisWellcome Trust-Medical Research Council Institute of Metabolic Science-Metabolic Research Laboratories, University of Cambridge, Cambridge, United Kingdom.
Fran EblingSchool of Life Sciences, University of Nottingham, Nottingham, United Kingdom.
Seth BlackshawSolomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Andrew FurleySchool of Biosciences, The University of Sheffield, Sheffield, United Kingdom.
Marysia PlaczekSchool of Biosciences, The University of Sheffield, Sheffield, United Kingdom.
University of Sheffield · GBUniversity of Nottingham · GBDiscovery Institute · USJohns Hopkins University · USMedical Research Council · GB

Funding

Development and function of hypothalamic Lhx6-positive neuronsR01MH126676 · NIMH · JOHNS HOPKINS UNIVERSITY · PI BLACKSHAW, SETH · 2021 to 2025
$2.0M
NIMH NIH HHS R01 MH126676Wellcome Trust
6 · The paper itself

Abstract

Hypothalamic tanycytes are neural stem and progenitor cells, but little is known of how they are regulated. Here we provide evidence that the cell adhesion molecule, NrCAM, regulates tanycytes in the adult niche. NrCAM is strongly expressed in adult mouse tanycytes. Immunohistochemical and

Indexed as

astrocyteshypothalamusneural cell adhesion moleculesneurogenesisNrCAMradial gliascRNA seqtanycyte

Identifiers

PMID35464310
PMCPMC9022636
OpenAlexW4226051239

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.