ArticleFrontiers in neuroscience2022
Why Would the Brain Need Dormant Neuronal Precursors?
Article in Frontiers in neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Immature Neurons in the Postnatal Brain: Markers, Modulation, and Involvement in Normal and Aberrant Plasticity.International journal of molecular sciences · 2026Review
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- Review
- Multispecies characterization of immature neurons in the mammalian amygdala reveals their expansion in primates.PLoS biology · 2025Article
- Adult neurogenesis and "immature" neurons in mammals: an evolutionary trade-off in plasticity?Brain structure & function · 2024Review
- Article
- Delayed maturation and migration of excitatory neurons in the juvenile mouse paralaminar amygdala.Neuron · 2024Article
- Which neurodevelopmental processes continue in humans after birth?Frontiers in neuroscience · 2024Article
- Article
- Consistency and Variation in Doublecortin and Ki67 Antigen Detection in the Brain Tissue of Different Mammals, including Humans.International journal of molecular sciences · 2023Article
- Age-related changes in layer II immature neurons of the murine piriform cortex.Frontiers in cellular neuroscience · 2023Article
- Immature excitatory neurons in the amygdala come of age during puberty.Developmental cognitive neuroscience · 2022Article
- How Widespread Are the "Young" Neurons of the Mammalian Brain?Frontiers in neuroscience · 2022Article
- Current progress and challenges in the development of brain tissue models: How to grow up the changeable brain in vitro?Journal of tissue engineeringReview
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2 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Dormant non-proliferative neuronal precursors (dormant precursors) are a unique type of undifferentiated neuron, found in the adult brain of several mammalian species, including humans. Dormant precursors are fundamentally different from canonical neurogenic-niche progenitors as they are generated exquisitely during the embryonic development and maintain a state of protracted postmitotic immaturity lasting up to several decades after birth. Thus, dormant precursors are not pluripotent progenitors, but to all effects extremely immature neurons. Recently, transgenic models allowed to reveal that with age virtually all dormant precursors progressively awaken, abandon the immature state, and become fully functional neurons. Despite the limited common awareness about these cells, the deep implications of recent discoveries will likely lead to revisit our understanding of the adult brain. Thus, it is timely to revisit and critically assess the essential evidences that help pondering on the possible role(s) of these cells in relation to cognition, aging, and pathology. By highlighting pivoting findings as well as controversies and open questions, we offer an exciting perspective over the field of research that studies these mysterious cells and suggest the next steps toward the answer of a crucial question: why does the brain need dormant neuronal precursors?
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