Evidence map›Paper›PMID 35464242›Full record

ArticleFood science and biotechnology2022

Resveratrol analogue, HS-1793, inhibits inflammatory mediator release from macrophages by interfering with the TLR4 mediated NF-κB activation.

Wol Soon Jo, Sung Dae Kim, Soo Kyung Jeong, Su Jung Oh, Moon Taek ParK, Chang Geun Lee, Young-Rok Kang, Min Ho Jeong

Open access · greenAbstract read
In one paragraph

Article in Food science and biotechnology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Wol Soon JoDepartment of Research Center, Dongnam Institute of Radiological and Medical Sciences, Jwadong-gil 40, Jangan-eup, Gijang-gun, Busan, 46033 Republic of Korea.
Sung Dae KimDepartment of Veterinary Medicine, College of Veterinary Medicine, Kyungpook National University, Daehak-ro 80, Buk-gu, Daegu, 41566 Republic of Korea.
Soo Kyung JeongDepartment of Research Center, Dongnam Institute of Radiological and Medical Sciences, Jwadong-gil 40, Jangan-eup, Gijang-gun, Busan, 46033 Republic of Korea.
Su Jung OhDepartment of Research Center, Dongnam Institute of Radiological and Medical Sciences, Jwadong-gil 40, Jangan-eup, Gijang-gun, Busan, 46033 Republic of Korea.
Moon Taek ParKDepartment of Research Center, Dongnam Institute of Radiological and Medical Sciences, Jwadong-gil 40, Jangan-eup, Gijang-gun, Busan, 46033 Republic of Korea.
Chang Geun LeeDepartment of Research Center, Dongnam Institute of Radiological and Medical Sciences, Jwadong-gil 40, Jangan-eup, Gijang-gun, Busan, 46033 Republic of Korea.
Young-Rok KangDepartment of Research Center, Dongnam Institute of Radiological and Medical Sciences, Jwadong-gil 40, Jangan-eup, Gijang-gun, Busan, 46033 Republic of Korea.
Min Ho JeongDepartment of Microbiology, Dong-A University College of Medicine, Daeshingongwon-gil 32, Seo-gu, Busan, 49236 Republic of Korea.
Dongnam Institute of Radiological & Medical Sciences · KRDong-A University · KRKyungpook National University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Resveratrol is known to have anti-inflammatory properties. However, high-dose resveratrol is required for optimal anti-inflammatory effects. HS-1793 is a derivative designed to be metabolically stable and more effective than resveratrol. We tested whether HS-1793 also has anti-inflammatory activity. HS-1793 effectively inhibited the mRNA and protein expression of lipopolysaccharide (LPS)-induced inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in macrophages. Therefore, the production of nitric oxide (NO) and prostaglandin E

Indexed as

Anti-inflammationHS-1793MacrophageResveratrol analogueTLR4·NF-κB

Identifiers

PMID35464242
PMCPMC8994813
OpenAlexW4220843844

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.