ReviewFrontiers in behavioral neuroscience2022
Neurobiology of Loneliness, Isolation, and Loss: Integrating Human and Animal Perspectives.
Review in Frontiers in behavioral neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
53 citing papers in PubMed, 2 syntheses or guidelines pooled it, 92 citations in OpenAlex.
- Psychosocial factors and the risk of cancer: An individual-participant data meta-analysis.Cancer · 2026Pooled it
- Biopsychosocial and Environmental Factors That Impact Brain-Gut-Microbiome Interactions in Obesity.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2026Pooled it
- Age and loneliness relate to reduced trust learning and alterations in amygdala function.iScience · 2026Article
- Multidimensional determinants of depression and non-depression in older adults: evidence from national data.BMC geriatrics · 2026Article
- Loneliness, affectivity and psychological distress in people living alone during the COVID-19 pandemic: a cluster analysis.Psicologia, reflexao e critica : revista semestral do Departamento de Psicologia da UFRGS · 2026Article
- Characterizing Loneliness and Health in US Adults: An analysis of 2024 National Health Interview Survey.medRxiv : the preprint server for health sciences · 2026Article
- Assessment of Emerging Technologies to Support Individuals With At-Risk Alcohol Consumption: Pilot Controlled Investigation Study.JMIR formative research · 2026Article
- Neural Mechanisms of Social Homeostasis: Dynamic Range Plasticity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Review
- Ethological Constraints and Welfare-Related Bias in Laboratory Mice: Implications of Housing, Lighting, and Social Environment.Animals : an open access journal from MDPI · 2026Review
- Social rank and social environment combinedly affect REM sleep in mice.Scientific reports · 2026Article
- Loneliness and cognitive decline among U.S. adults: A stratified analysis of the BRFSS.PloS one · 2026Article
- Relationships between primal emotional systems and the sense of loneliness: The mediating role of early maladaptive schemas.PloS one · 2026Article
- Social Housing of Postoperative Animals to Support Animal Welfare.Journal of the American Association for Laboratory Animal Science : JAALAS · 2026Review
- Review
- Duration-dependent effects of social isolation on reintegration behavior in the swarming soldier crab, Mictyris guinotae.PloS one · 2026Article
- Loneliness in adolescents and youth with bipolar disorder: a scoping review.Frontiers in psychiatry · 2026Review
- Loneliness as a sex-specific risk factor for cognitive aging.Frontiers in human neuroscience · 2026Review
- Social bonds and health: exploring the impact of social relations on oxytocin and brain-gut communication in shaping obesity.Gut microbes · 2025Article
- Association between loneliness and hippocampal responses to dynamic social stimuli in psychotic disorders.Psychological medicine · 2025Article
- Hormonal and Behavioral Consequences of Social Isolation and Loneliness: Neuroendocrine Mechanisms and Clinical Implications.International journal of molecular sciences · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
In social species such as humans, non-human primates, and even many rodent species, social interaction and the maintenance of social bonds are necessary for mental and physical health and wellbeing. In humans, perceived isolation, or loneliness, is not only characterized by physical isolation from peers or loved ones, but also involves negative perceptions about social interactions and connectedness that reinforce the feelings of isolation and anxiety. As a complex behavioral state, it is no surprise that loneliness and isolation are associated with dysfunction within the ventral striatum and the limbic system - brain regions that regulate motivation and stress responsiveness, respectively. Accompanying these neural changes are physiological symptoms such as increased plasma and urinary cortisol levels and an increase in stress responsivity. Although studies using animal models are not perfectly analogous to the uniquely human state of loneliness, studies on the effects of social isolation in animals have observed similar physiological symptoms such as increased corticosterone, the rodent analog to human cortisol, and also display altered motivation, increased stress responsiveness, and dysregulation of the mesocortical dopamine and limbic systems. This review will discuss behavioral and neuropsychological components of loneliness in humans, social isolation in rodent models, and the neurochemical regulators of these behavioral phenotypes with a neuroanatomical focus on the corticostriatal and limbic systems. We will also discuss social loss as a unique form of social isolation, and the consequences of bond disruption on stress-related behavior and neurophysiology.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.