ArticleInterface focus2022
Cycle dynamics and synchronization in a coupled network of peripheral circadian clocks.
Article in Interface focus, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 12 citations in OpenAlex.
- Circadian clock model with sequestration repression motif: existence of periodic orbits and entrainment properties.Interface focus · 2025Article
- Scientific parallels of sleep physiology in the Qur'anic narrative of the Companions of the Cave "the Cave Sleepers".Sleep & breathing = Schlaf & Atmung · 2025Review
- Oscillator death in coupled biochemical oscillators.Mathematics of control, signals, and systems : MCSS · 2023Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The intercellular interactions between peripheral circadian clocks, located in tissues and organs other than the suprachiasmatic nuclei of the hypothalamus, are still very poorly understood. We propose a theoretical and computational study of the coupling between two or more clocks, using a calibrated, reduced model of the circadian clock to describe some synchronization properties between peripheral cellular clocks. Based on a piecewise linearization of the dynamics of the mutual CLOCK:BMAL1/PER:CRY inactivation term, we suggest a segmentation of the circadian cycle into six stages, to help analyse different types of synchronization between two clocks, including single stage duration, total period and maximal amplitudes. Finally, our model reproduces some recent experimental results on the effects of different regimes of time-restricted feeding in liver circadian clocks of mice.
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