Evidence map›Paper›PMID 35464049›Full record

ArticleFrontiers in endocrinology2022

Loss of Adipocyte STAT5 Confers Increased Depot-Specific Adiposity in Male and Female Mice That Is Not Associated With Altered Adipose Tissue Lipolysis.

Allison J Richard, Hardy Hang, Timothy D Allerton, Peng Zhao, Tamra Mendoza, Sujoy Ghosh, Carrie M Elks, Jacqueline M Stephens

Open access · goldAbstract read
In one paragraph

Article in Frontiers in endocrinology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Allison J RichardAdipocyte Biology Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, United States.
Hardy HangAdipocyte Biology Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, United States.
Timothy D AllertonAdipocyte Biology Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, United States.
Peng ZhaoAdipocyte Biology Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, United States.
Tamra MendozaAdipocyte Biology Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, United States.
Sujoy GhoshCardiovascular and Metabolic Disease Program and Center for Computational Biology, Duke-NUS Graduate Medical School, Singapore, Singapore.
Carrie M ElksAdipocyte Biology Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, United States.
Jacqueline M StephensAdipocyte Biology Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, United States.
Pennington Biomedical Research Center · USDuke-NUS Medical School · SGLouisiana State University · US

Funding

Research BaseP30DK072476 · NIDDK · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI ROBERT A KESTERSON · 2005 to 2026
$26.5M
Transgenics CoreP30GM118430 · NIGMS · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI GETTYS, THOMAS W · 2016 to 2020
$5.8M
The regulation and activation of STATs in adipocytesR01DK052968 · NIDDK · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI STEPHENS, JACQUELINE M · 1999 to 2018
$5.0M
Sable Systems Promethion for Mouse Metabolic AnalysisS10OD023703 · OD · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI MORRISON, CHRISTOPHER D · 2017 to 2017
$626k
Oncostatin M as a mediator of adipose tissue immune balanceR03DK122121 · NIDDK · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI ELKS, CARRIE M · 2020 to 2021
$222k
NIDDK NIH HHS P30 DK072476NIDDK NIH HHS R01 DK052968NIDDK NIH HHS R03 DK122121NIGMS NIH HHS P30 GM118430NIH HHS S10 OD023703
6 · The paper itself

Abstract

STATs (Signal Transducers and Activators of Transcription) 5A and 5B are induced during adipocyte differentiation and are primarily activated by growth hormone (GH) and prolactin in fat cells. Previous studies in mice lacking adipocyte GH receptor or STAT5 support their roles in lipolysis-mediated reduction of adipose tissue mass. Male and female mice harboring adipocyte-specific deletion of both STAT5 genes (STAT5

Indexed as

AdiposityLipolysisAdipocytesAdipose TissueAnimalsFemaleMaleMiceObesitySTAT5 Transcription FactorSTAT5 Transcription Factoradiposegrowth hormonesexual dimorphismSTATstranscription

Identifiers

PMID35464049
PMCPMC9022209
OpenAlexW4225815895

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.