SynthesisFrontiers in nutrition2022
Associations of Dietary Vitamin C and E Intake With Depression. A Meta-Analysis of Observational Studies.
Synthesis in Frontiers in nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Identifying transdiagnostically relevant risk and protective factors for internalizing psychopathology: An umbrella review of longitudinal meta-analyses.Journal of psychiatric research · 2023Pooled it
- Effect of Nutritional Factors on Mental Health Problems in Autism Spectrum Disorder: A Narrative Synthesis of Current Evidence.Brain and behavior · 2026Review
- Consequences of Western and Mediterranean Diets' Nutrients on the Microbiota-Gut-Brain Axis.Nutrients · 2026Review
- Associations between composite dietary antioxidant index and depressive symptoms among pregnant and postpartum women.BMC pregnancy and childbirth · 2026Article
- Association between dietary patterns and depressive symptoms in Chinese adults.Asia Pacific journal of clinical nutrition · 2026Article
- Oxidative Stress in Treatment-Resistant and Refractory Depression: A Hidden Therapeutic Target?Molecular neurobiology · 2026Review
- Plasma vitamin C levels are associated with brain structural networks on MRI: A large cohort study.PloS one · 2026Article
- Serotonergic Regulation of Photic Signaling of Ascorbate in the Rat Thalamus.Molecular neurobiology · 2025Article
- Factors influencing mental health outcomes among university students: a cross-sectional study in Bangladesh.BMJ open · 2025Article
- The association of vitamin deficiency with depression risk in late-life depression: a review.Frontiers in nutrition · 2025Review
- Article
- Sex-specific differences in the association of dietary riboflavin intake with depression and suicidal ideation.Frontiers in nutrition · 2025Article
- The Risk of Depressive Symptoms according to the Dietary Intake of Vitamin C.Neuropsychobiology · 2025Article
- The association between neutrophil percentage-to-albumin ratio (NPAR) and depression among US adults: a cross-sectional study.Scientific reports · 2024Article
- The Dietary Inflammatory Index and Its Associations with Biomarkers of Nutrients with Antioxidant Potential, a Biomarker of Inflammation and Multiple Long-Term Conditions.Antioxidants (Basel, Switzerland) · 2024Article
- Article
- Association between Dietary Antioxidant Capacity in Midlife and Depressive Symptoms in Late Life: The Singapore Chinese Health Study.Antioxidants (Basel, Switzerland) · 2024Article
- Association of composite dietary antioxidant index with depression and all-cause mortality in middle-aged and elderly population.Scientific reports · 2024Article
- Association between vitamin C in serum and trouble sleeping based on NHANES 2017-2018.Scientific reports · 2024Article
- Higher serum ascorbic acid levels are associated with lower depression prevalence in US adults: a case-control study.Frontiers in nutrition · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: The associations of dietary vitamin C and E intake with depression remains conflicting. This meta-analysis of observational study was therefore employed to clarify the issue further. Methods: An extensive literature review (PubMed, Web of Science and Embase) was performed in January 2022 to identify the observational studies on the associations of dietary vitamin C and E intake with depression. The pooled relative risk (RR) of depression for the highest versus lowest dietary vitamin C and E intake category, and the weighted mean difference (WMD) of dietary vitamin C and E intake for depression versus control subjects, were calculated. Results: A total of 25 observational studies (91966 participants) were included in this meta-analysis. The overall multi-variable adjusted RR demonstrated that dietary vitamin C intake was inversely associated with depression (RR = 0.72, 95% CI: 0.57 to 0.91; Conclusion: The results of this meta-analysis suggest that both dietary vitamin C and E intake is inversely associated with depression. However, due to the limited evidence, more well-designed prospective cohort studies are still needed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.