Evidence map›Paper›PMID 35463992›Full record

ArticleBioMed research international2022

Immunotherapy Mechanism of Esophageal Squamous Cell Carcinoma with the Effect of STK11/AMPK Signaling Pathway.

Yang Xia, Peng Wang, Yunyao Ye, Sihui Zhang, Guangzhi Sun, Jie Xu, Gaohua Han

RetractedOpen access · hybridAbstract readRetracted Publication
In one paragraph

Article in BioMed research international, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Yang XiaDepartment of Oncology, Taizhou People's Hospital, Taizhou, 225300 Jiangsu Province, China.
Peng WangDepartment of Oncology, Taizhou People's Hospital, Taizhou, 225300 Jiangsu Province, China.
Yunyao YeDepartment of Oncology, Taizhou People's Hospital, Taizhou, 225300 Jiangsu Province, China.
Sihui ZhangDepartment of Oncology, Taizhou People's Hospital, Taizhou, 225300 Jiangsu Province, China.
Guangzhi SunDepartment of Oncology, Taizhou People's Hospital, Taizhou, 225300 Jiangsu Province, China.
Jie XuDepartment of Oncology, Taizhou People's Hospital, Taizhou, 225300 Jiangsu Province, China.
Gaohua HanDepartment of Oncology, Taizhou People's Hospital, Taizhou, 225300 Jiangsu Province, China.ORCID https://orcid.org/0000-0003-3200-5378
Nantong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study was aimed at exploring the mechanism of serine threonine protein kinase 11 (STK11)/Adenosine 5'-monophosphate-activated protein kinase (AMPK) signaling pathway after immunotherapy for esophageal squamous cell carcinoma (ESCC), providing basic information for the clinical treatment of ESCC. In this study, tissue specimens from 100 patients with ESCC who underwent surgical treatment in Taizhou People's Hospital (group A) and 20 patients with recurrent or metastatic ESCC who received second-line immunotherapy (group B) were collected. The real-time fluorescent quantitative polymerase chain reaction (PCR) (RT-qPCR) technology was used to detect the expression levels of STK11, interferon-

Indexed as

AMP-Activated Protein Kinase KinasesAMP-Activated Protein KinasesEsophageal NeoplasmsEsophageal Squamous Cell CarcinomaCell Line, TumorGene Expression Regulation, NeoplasticHumansImmunotherapyInterleukin-6Protein Serine-Threonine KinasesSignal TransductionVascular Endothelial Growth Factor AAMP-Activated Protein Kinase KinasesAMP-Activated Protein KinasesInterleukin-6PRKAA1 protein, humanProtein Serine-Threonine KinasesSTK11 protein, humanVascular Endothelial Growth Factor A

Identifiers

PMID35463992
PMCPMC9033337
OpenAlexW4223937459

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.