Evidence map›Paper›PMID 35463966›Full record

ArticleFrontiers in molecular biosciences2022

Multiplatform Metabolomics Studies of Human Cancers With NMR and Mass Spectrometry Imaging.

Anya B Zhong, Isabella H Muti, Stephen J Eyles, Richard W Vachet, Kristen N Sikora, Cedric E Bobst, David Calligaris, Sylwia A Stopka, Jeffery N Agar, Chin-Lee Wu and 5 more

Abstract read
In one paragraph

Article in Frontiers in molecular biosciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Review
  6. Article
  7. Multiplatform untargeted metabolomics.Magnetic resonance in chemistry : MRC · 2023
    Review
  8. Article
  9. NMR-based metabolomics: Where are we now and where are we going?Progress in nuclear magnetic resonance spectroscopy
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Anya B ZhongMassachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
Isabella H MutiMassachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
Stephen J EylesDepartment of Biochemistry and Molecular Biology, University of Massachusetts-Amherst, Amherst, MA, United States.
Richard W VachetDepartment of Biochemistry and Molecular Biology, University of Massachusetts-Amherst, Amherst, MA, United States.
Kristen N SikoraDepartment of Biochemistry and Molecular Biology, University of Massachusetts-Amherst, Amherst, MA, United States.
Cedric E BobstDepartment of Biochemistry and Molecular Biology, University of Massachusetts-Amherst, Amherst, MA, United States.
David CalligarisDepartment of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
Sylwia A StopkaDepartment of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
Jeffery N AgarDepartment of Chemistry and Chemical Biology, Northeastern University, Boston, MA, United States.
Chin-Lee WuMassachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
Mari A Mino-KenudsonMassachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
Nathalie Y R AgarDepartment of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
David C ChristianiMassachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
Igor A KaltashovDepartment of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
Leo L ChengMassachusetts General Hospital, Harvard Medical School, Boston, MA, United States.

Funding

TRD 3 - Enabling Technologies for Intraprocedural GuidanceP41EB028741 · NIBIB · BRIGHAM AND WOMEN'S HOSPITAL · PI Oliver Jonas · 2021 to 2026
$10.7M
Characterizing Prostate Cancer By ex vivo MRS SignaturesR01CA115746 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI CHENG, LEO L · 2006 to 2017
$6.4M
CHEMISTRY-BIOLOGY INTERFACE PREDOCTORAL TRAINING GRANTST32GM008515 · NIGMS · UNIVERSITY OF MASSACHUSETTS AMHERST · PI THOMPSON, LYNMARIE K. · 1995 to 2020
$4.3M
Metabolomic characterization of normal aging and Alzheimer's disease under anesthesia- surgery stimuliR01AG070257 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI JENKINS, BRUCE G, XIE, ZHONGCONG · 2021 to 2025
$3.9M
Chemistry-Biology Interface Predoctoral Training GrantT32GM139789 · NIGMS · UNIVERSITY OF MASSACHUSETTS AMHERST · PI ERIC Robert STRIETER · 2021 to 2026
$3.4M
Upgrade of Console for 600 MHz MR SpectrometerS10OD023406 · OD · MASSACHUSETTS GENERAL HOSPITAL · PI CHENG, LEO L · 2017 to 2017
$600k
NCI NIH HHS R01 CA115746NIA NIH HHS R01 AG070257NIBIB NIH HHS P41 EB028741NIGMS NIH HHS T32 GM008515NIGMS NIH HHS T32 GM139789NIH HHS S10 OD023406
6 · The paper itself

Abstract

The status of metabolomics as a scientific branch has evolved from proof-of-concept to applications in science, particularly in medical research. To comprehensively evaluate disease metabolomics, multiplatform approaches of NMR combining with mass spectrometry (MS) have been investigated and reported. This mixed-methods approach allows for the exploitation of each individual technique's unique advantages to maximize results. In this article, we present our findings from combined NMR and MS imaging (MSI) analysis of human lung and prostate cancers. We further provide critical discussions of the current status of NMR and MS combined human prostate and lung cancer metabolomics studies to emphasize the enhanced metabolomics ability of the multiplatform approach.

Indexed as

imaginglung cancermass spectrometrymetabolomicsnuclear magnetic resonance spectroscopyprostate cancer

Identifiers

PMID35463966
PMCPMC9024335

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.