Evidence map›Paper›PMID 35463850›Full record

ArticleFrontiers in synaptic neuroscience2022

Complementary Use of Super-Resolution Imaging Modalities to Study the Nanoscale Architecture of Inhibitory Synapses.

Sara E Gookin, Matthew R Taylor, Samantha L Schwartz, Matthew J Kennedy, Mark L Dell'Acqua, Kevin C Crosby, Katharine R Smith

Open access · goldAbstract read
In one paragraph

Article in Frontiers in synaptic neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Sara E GookinDepartment of Pharmacology, University of Colorado School of Medicine, Aurora, CO, United States.
Matthew R TaylorDepartment of Pharmacology, University of Colorado School of Medicine, Aurora, CO, United States.
Samantha L SchwartzDepartment of Pharmacology, University of Colorado School of Medicine, Aurora, CO, United States.
Matthew J KennedyDepartment of Pharmacology, University of Colorado School of Medicine, Aurora, CO, United States.
Mark L Dell'AcquaDepartment of Pharmacology, University of Colorado School of Medicine, Aurora, CO, United States.
Kevin C CrosbyDepartment of Pharmacology, University of Colorado School of Medicine, Aurora, CO, United States.
Katharine R SmithDepartment of Pharmacology, University of Colorado School of Medicine, Aurora, CO, United States.
University of Colorado Denver · US

Funding

Regulation of Calcium-permeable AMPA Receptors by AKAP79 Postsynaptic SignalingR01NS040701 · NINDS · UNIVERSITY OF COLORADO DENVER · PI DELL'ACQUA, MARK L · 2001 to 2023
$7.7M
Novel approaches for interrogating and manipulating synaptic function, structure and plasticityR35NS116879 · NINDS · UNIVERSITY OF COLORADO DENVER · PI Matthew J Kennedy · 2020 to 2026
$4.0M
L-type Ca2+ Channel Spike Regulation of Spine Structural Plasticity and Excitation-Transcription CouplingR01MH123700 · NIMH · UNIVERSITY OF COLORADO DENVER · PI DELL'ACQUA, MARK L · 2021 to 2025
$2.8M
Nanoscale organization of the inhibitory synapse during synaptic plasticityR01MH119154 · NIMH · UNIVERSITY OF COLORADO DENVER · PI SMITH, KATHARINE RACHEL · 2020 to 2024
$2.0M
NIMH NIH HHS R01 MH119154NIMH NIH HHS R01 MH123700NINDS NIH HHS R01 NS040701NINDS NIH HHS R35 NS116879
6 · The paper itself

Abstract

The nanoscale architecture of synapses has been investigated using multiple super-resolution methods, revealing a common modular structure for scaffolds, neurotransmitter receptors, and presynaptic proteins. This fundamental organization of proteins into subsynaptic domains (SSDs) is thought to be important for synaptic function and plasticity and common to many types of synapses. Using 3D super-resolution Structured Illumination Microscopy (3D-SIM), we recently showed that GABAergic inhibitory synapses exhibit this nanoscale organizational principle and are composed of SSDs of GABA

Indexed as

3D-SIMdSTORMgephyrininhibitory synapseneuroligin-2super-resolution microscopy

Identifiers

PMID35463850
PMCPMC9024107
OpenAlexW4226149426

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.