Evidence map›Paper›PMID 35463688›Full record

ArticleJournal of healthcare engineering2022

Immunohistochemistry Study of OY-TES-1 Location in Fetal and Adult Human Tissues.

Jun Fu, Yingying Ge, Qingmei Zhang, Yongda Lin, Chang Liu, Weixia Nong, Xin Luo, Shaowen Xiao, Xiaoxun Xie, Bin Luo

RetractedOpen access · hybridAbstract readRetracted Publication
In one paragraph

Article in Journal of healthcare engineering, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 62% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Jun FuDepartment of Histology & Embryology, School of Pre-clinical Medicine, Guangxi Medical University, Nanning 530021, China.
Yingying GeDepartment of Histology & Embryology, School of Pre-clinical Medicine, Guangxi Medical University, Nanning 530021, China.
Qingmei ZhangGuangxi Colleges and Universities Key Laboratory Research of Preclinical Medicine, Guangxi Medical University, Nanning 530021, China.
Yongda LinDepartment of Histology & Embryology, School of Pre-clinical Medicine, Guangxi Medical University, Nanning 530021, China.
Chang LiuDepartment of Neurosurgery, First Affiliated Hospital, Guangxi Medical University, Nanning 530021, China.
Weixia NongDepartment of Histology & Embryology, School of Pre-clinical Medicine, Guangxi Medical University, Nanning 530021, China.
Xin LuoDepartment of Histology & Embryology, School of Pre-clinical Medicine, Guangxi Medical University, Nanning 530021, China.
Shaowen XiaoDepartment of Neurosurgery, First Affiliated Hospital, Guangxi Medical University, Nanning 530021, China.
Xiaoxun XieGuangxi Colleges and Universities Key Laboratory Research of Preclinical Medicine, Guangxi Medical University, Nanning 530021, China.ORCID 0000-0001-6683-5180
Bin LuoGuangxi Colleges and Universities Key Laboratory Research of Preclinical Medicine, Guangxi Medical University, Nanning 530021, China.ORCID 0000-0002-1589-1147
Guangxi Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

OY-TES-1 is reportedly involved in carcinogenesis and spermatogenesis. However, the tissue distribution of OY-TES-1 in the normal human body remains elusive. This study detected OY-TES-1 expression in human fetal and adult normal tissues by immunohistochemistry. We identified a general principle of OY-TES-1 expression. The expression of OY-TES-1 was found in neurons, smooth muscle cells, and cardiac muscle cells from both fetuses and adults. The connective tissue showed no specific staining throughout the fetal and adult samples. With OY-TES-1-positive staining of the epithelium irregular, OY-TES-1 was strongly expressed in the epithelium of the skin and bladder, as well as hepatocytes, pancreatic islets, and acinous cells during the fetal stage but was not detected in the postnatal period. In contrast to the epithelium of blood vessels, the fetal and adult central hepatic vein and glomeruli showed negative expression of the OY-TES-1 protein. Sex-dimorphism was observed in the distribution of OY-TES-1 in male and female germ cells. Collectively, our results indicate that OY-TES-1 is a member of the cancer-testis antigen and autoantigen, with tissue-specific and period-specific expression patterns, revealing potential contributions of OY-TES-1 to the diagnosis and therapeutic treatment for neoplasms and infertility.

Indexed as

Carrier ProteinsNeoplasmsAdultFemaleFetusHumansImmunohistochemistryMaleCarrier Proteins

Identifiers

PMID35463688
PMCPMC9020931
OpenAlexW4224138426

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.