Evidence map›Paper›PMID 35463672›Full record

ReviewJournal of healthcare engineering2022

The Current Status of SSRP1 in Cancer: Tribulation and Road Ahead.

Shengnan Jia, Baofeng Guo, Lihui Wang, Liping Peng, Ling Zhang

RetractedOpen access · hybridAbstract readReviewRetracted Publication
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of healthcare engineering, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Shengnan JiaDepartment of Respiratory Medicine, The First Hospital of Jilin University, 71 Xinmin Street, Changchun, Jilin 130021, China.
Baofeng GuoDepartment of Plastic Surgery, China-Japan Union Hospital of Jilin University, Changchun, China.
Lihui WangDepartment of Respiratory Medicine, The First Hospital of Jilin University, 71 Xinmin Street, Changchun, Jilin 130021, China.
Liping PengDepartment of Respiratory Medicine, The First Hospital of Jilin University, 71 Xinmin Street, Changchun, Jilin 130021, China.ORCID 0000-0002-1646-2491
Ling ZhangKey Laboratory of Pathobiology, Ministry of Education and Department of Pathophysiology, College of Basic Medical Sciences, Jilin University, 126 Xinmin Street, Changchun, Jilin 130021, China.ORCID 0000-0002-0298-8855
Jilin University · CNUnion Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Methods: We search PubMed and Web of Sciences with keywords "SSRP1" and "Cancer." Only English literature was included, and conference papers and abstract were all excluded. Results: Transcription factors are classified into three groups based on their DNA binding motifs: simple helix-loop-helix (bHLH), classical zinc fingers (ZF-TFs), and homeodomains. The tumor-suppressive miR-497 (microRNA-497) acted as an undesirable regulator of SSRP1 upregulation, which led to tumor growth. The siRNA (small interfering RNA) knockdown of SSRP1 hindered cell proliferation along with incursion and glioma cell migration. Through the AKT (also known as protein kinase B) signaling pathway, SSRP1 silencing affected cancer apoptosis and cell proliferation. Conclusion: The MAPK (mitogen-activated protein kinase) signaling pathway's phosphorylation was suppressed when SSRP1 was depleted. The effect of curaxins on p53 and NF-B (nuclear factor-

Indexed as

GliomaMicroRNAsApoptosisCell Line, TumorChromatinDNA-Binding ProteinsHigh Mobility Group ProteinsHumansTranscriptional Elongation FactorsChromatinDNA-Binding ProteinsHigh Mobility Group ProteinsMicroRNAsMIRN497 microRNA, humanSSRP1 protein, humanTranscriptional Elongation Factors

Identifiers

PMID35463672
PMCPMC9020922
OpenAlexW4224080037

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.