Evidence map›Paper›PMID 35463635›Full record

ArticleFrontiers in cellular and infection microbiology2022

Contribution of

Derek Fleming, Brandon Niese, Whitni Redman, Emily Vanderpool, Vernita Gordon, Kendra P Rumbaugh

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 36 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Review
  11. Review
  12. Article
  13. Skin microbiota and diabetic foot ulcers.Frontiers in microbiology · 2025
    Review
  14. Simulated microgravity induces time-dependent enhancement ofCurrent research in microbial sciences · 2025
    Article
  15. Review
  16. Article
  17. Modeling Host-Pathogen Interactions inInternational journal of molecular sciences · 2024
    Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Derek FlemingDepartment of Surgery, Texas Tech University Health Sciences, Lubbock, TX, United States.
Brandon NieseDepartment of Physics, Center for Nonlinear Dynamics, The University of Texas at Austin, Austin TX, United States.
Whitni RedmanDepartment of Surgery, Texas Tech University Health Sciences, Lubbock, TX, United States.
Emily VanderpoolDepartment of Surgery, Texas Tech University Health Sciences, Lubbock, TX, United States.
Vernita GordonDepartment of Physics, Center for Nonlinear Dynamics, The University of Texas at Austin, Austin TX, United States.
Kendra P RumbaughDepartment of Surgery, Texas Tech University Health Sciences, Lubbock, TX, United States.
Texas Tech University Health Sciences Center · USThe University of Texas at Austin · US

Funding

Assessing the roles of biofilm structure and mechanics in pathogenic, persistent infectionsR01AI121500 · NIAID · UNIVERSITY OF TEXAS AT AUSTIN · PI GORDON, VERNITA DIANE · 2017 to 2020
$1.5M
Utilizing Glycoside Hydrolases to Degrade Biofilms in WoundsR21AI137462 · NIAID · TEXAS TECH UNIVERSITY HEALTH SCIS CENTER · PI RUMBAUGH, KENDRA P · 2019 to 2020
$286k
NIAID NIH HHS R01 AI121500NIAID NIH HHS R21 AI137462
6 · The paper itself

Abstract

Biofilms are the cause of most chronic bacterial infections. Living within the biofilm matrix, which is made of extracellular substances, including polysaccharides, proteins, eDNA, lipids and other molecules, provides microorganisms protection from antimicrobials and the host immune response. Exopolysaccharides are major structural components of bacterial biofilms and are thought to be vital to numerous aspects of biofilm formation and persistence, including adherence to surfaces, coherence with other biofilm-associated cells, mechanical stability, protection against desiccation, binding of enzymes, and nutrient acquisition and storage, as well as protection against antimicrobials, host immune cells and molecules, and environmental stressors. However, the contribution of specific exopolysaccharide types to the pathogenesis of biofilm infection is not well understood. In this study we examined whether the absence of the two main exopolysaccharides produced by the biofilm former

Indexed as

Pseudomonas InfectionsWound InfectionAnimalsBacterial ProteinsBiofilmsMicePolysaccharides, BacterialPseudomonas aeruginosaBacterial Proteinsexopolysaccharide, PseudomonasPolysaccharides, BacterialaggregatebiofilmexopolysaccharidesPelPseudomonas aeruginosaPslwound infection

Identifiers

PMID35463635
PMCPMC9021892
OpenAlexW4226161340

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.