Evidence map›Paper›PMID 35463625›Full record

ReviewPhytomedicine plus : international journal of phytotherapy and phytopharmacology2022

Herbal medications and natural products for patients with covid-19 and diabetes mellitus: Potentials and challenges.

Abdurrahman Pharmacy Yusuf, Jian-Ye Zhang, Jing-Quan Li, Aliyu Muhammad, Murtala Bello Abubakar

Open access · goldAbstract readReview
In one paragraph

Review in Phytomedicine plus : international journal of phytotherapy and phytopharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.3field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Review
  6. The Effects of Propolis on Viral Respiratory Diseases.Molecules (Basel, Switzerland) · 2023
    Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 5 institutions in 2 countries.

Abdurrahman Pharmacy YusufDepartment of Biochemistry, School of Life Sciences, Federal University of Technology, P.M.B 65, Minna, Niger State, Nigeria.
Jian-Ye ZhangGuangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology, the NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences and the Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou 511436, P.R. China.
Jing-Quan LiThe first Affiliated Hospital, Hainan Medical University, Haikou, P.R. China.
Aliyu MuhammadDepartment of Biochemistry, Faculty of Life Sciences, Ahmadu Bello University Zaria, 810107, Kaduna State, Nigeria.
Murtala Bello AbubakarCentre for Advanced Medical Research and Training, Usmanu Danfodiyo University, Sokoto, Nigeria.
Ahmadu Bello University · NGFederal University of Technology Minna · NGHainan Medical University · CNState Key Laboratory of Respiratory Disease · CNUsmanu Danfodiyo University · NG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The presence of diabetes mellitus (DM) among COVID-19 patients is associated with increased hospitalization, morbidity, and mortality. Evidence has shown that hyperglycemia potentiates SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) infection and plays a central role in severe COVID-19 and diabetes comorbidity. In this review, we explore the therapeutic potentials of herbal medications and natural products in the management of COVID-19 and DM comorbidity and the challenges associated with the preexisting or concurrent use of these substances. Methods: Research papers that were published from January 2016 to December 2021 were retrieved from PubMed, ScienceDirect, and Google Scholar databases. Papers reporting clinical evidence of antidiabetic activities and any available evidence of the anti-COVID-19 potential of ten selected natural products were retrieved and analyzed for discussion in this review. Results: A total of 548 papers (73 clinical trials on the antidiabetic activities of the selected natural products and 475 research and review articles on their anti-COVID-19 potential) were retrieved from the literature search for further analysis. A total of 517 articles (reviews and less relevant research papers) were excluded. A cumulative sum of thirty-one (31) research papers (20 clinical trials and 10 others) met the criteria and have been discussed in this review. Conclusion: The findings of this review suggest that phenolic compounds are the most promising phytochemicals in the management of COVID-19 and DM comorbidity. Curcumin and propolis have shown substantial evidence against COVID-19 and DM in humans and are thus, considered the best potential therapeutic options.

Indexed as

8-OHDG, 8-hydroxy-2’-deoxyguanosineACE2ACE2, Angiotensin-converting enzyme 2ADMA, asymmetric de-methyl-arginineARDS, acute respiratory distress syndromeComorbidityCOVID-19DiabetesDM, diabetes mellitusFBS, fasting blood sugarGLUT-4, glucose transporter-4GSK-3β, glycogen synthase kinase-3βHDL, high-density lipoproteinHerbal medicationHOMA, homeostasis model assessmenths-CRP, high-sensitivity C-reactive proteinIAPP, islet amyloid polypeptideIFNAR2, interferon-alpha receptor 2IFN, interferonIL-6, interleukin-6LDL, low-density lipoproteinMDA, malondialdehydeMpro, main proteaseNatural productsPLpro, papain-like proteasePON1, paraoxonase-1RBD, receptor-binding domainRCT, randomized control trialRdRp, RNA-dependent RNA polymeraseSARS-CoV-2, severe acute respiratory syndrome coronavirus-2SFJDC, Shufeng Jiedu CapsuleT1D, type 1 diabetesT2D, type 2 diabetesTAC, total antioxidant capacityTMPRSS2, transmembrane protease serine 2

Identifiers

PMID35463625
PMCPMC9014648
OpenAlexW4223944987

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.