Evidence map›Paper›PMID 35463198›Full record

ArticleCarbon2022

Structure-Activity Relationship of Carbon Nitride Dots in Inhibiting Tau Aggregation.

Yiqun Zhou, Nabin Kandel, Mattia Bartoli, Leonardo F Serafim, Ahmed E ElMetwally, Sophia M Falkenberg, Xavier E Paredes, Christopher J Nelson, Nathan Smith, Elisa Padovano and 10 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Carbon, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 35 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 5 institutions in 3 countries.

Yiqun ZhouDepartment of Chemistry, University of Miami, Coral Gables, FL 33146, USA.
Nabin KandelDepartment of Biological Sciences, Rensselaer Polytechnic Institute, NY 12180, USA.
Mattia BartoliCenter for Sustainable Future, Italian Institute of Technology, Via Livorno 60, Turin 10144, Italy.
Leonardo F SerafimDepartment of Chemistry, University of Miami, Coral Gables, FL 33146, USA.
Ahmed E ElMetwallyDepartment of Chemistry, University of Miami, Coral Gables, FL 33146, USA.
Sophia M FalkenbergDepartment of Chemistry, University of Miami, Coral Gables, FL 33146, USA.
Xavier E ParedesDepartment of Chemistry, University of Miami, Coral Gables, FL 33146, USA.
Christopher J NelsonDepartment of Chemistry, University of Miami, Coral Gables, FL 33146, USA.
Nathan SmithDepartment of Biological Sciences, Rensselaer Polytechnic Institute, NY 12180, USA.
Elisa PadovanoDepartment of Applied Science and Technology, Politecnico di Torino, Italy.
Wei ZhangDepartment of Chemistry, University of Miami, Coral Gables, FL 33146, USA.
Keenan J MintzDepartment of Chemistry, University of Miami, Coral Gables, FL 33146, USA.
Braulio C L B FerreiraDepartment of Chemistry, University of Miami, Coral Gables, FL 33146, USA.
Emel Kirbas CilingirDepartment of Chemistry, University of Miami, Coral Gables, FL 33146, USA.
Jiuyan ChenDepartment of Chemistry, University of Miami, Coral Gables, FL 33146, USA.
Sujit K ShahDepartment of Chemistry, University of Miami, Coral Gables, FL 33146, USA.
Rajeev PrabhakarDepartment of Chemistry, University of Miami, Coral Gables, FL 33146, USA.
Alberto TagliaferroDepartment of Applied Science and Technology, Politecnico di Torino, Italy.
Chunyu WangDepartment of Biological Sciences, Rensselaer Polytechnic Institute, NY 12180, USA.
Roger M LeblancDepartment of Chemistry, University of Miami, Coral Gables, FL 33146, USA.
University of Miami · USRensselaer Polytechnic Institute · USPolitecnico di Torino · ITGeorgia Institute of Technology · USItalian Institute of Technology · IT

Funding

Heparan Sulfate 3-O-Sulfation in Transcellular Propagation of Tauopathy in Alzheimer's DiseaseRF1AG069039 · NIA · RENSSELAER POLYTECHNIC INSTITUTE · PI LINHARDT, ROBERT J, LIU, JIAN · 2020 to 2020
$2.6M
Predoctoral Training Program for Alzheimer’s Disease at the Interface of Data Science, Engineering and BiologyT32AG078123 · NIA · RENSSELAER POLYTECHNIC INSTITUTE · PI Chunyu Wang · 2023 to 2026
$974k
NIA NIH HHS RF1 AG069039NIA NIH HHS T32 AG078123
6 · The paper itself

Abstract

Due to the numerous failed clinical trials of anti-amyloid drugs, microtubule associated protein tau (MAPT) now stands out as one of the most promising targets for AD therapy. In this study, we report for the first time the structure-dependent MAPT aggregation inhibition of carbon nitride dots (CNDs). CNDs have exhibited great promise as a potential treatment of Alzheimer's disease (AD) by inhibiting the aggregation of MAPT. In order to elucidate its structure-activity relationship, CNDs were separated via column chromatography and five fractions with different structures were obtained that were characterized by multiple spectroscopy methods. The increase of surface hydrophilic functional groups is consistent with the increase of polarity from fraction 1 to 5. Particle sizes (1-2 nm) and zeta potentials (~-20 mV) are similar among five fractions. With the increase of polarity from fraction 1 to 5, their MAPT aggregation inhibition capacity was weakened. This suggests hydrophobic interactions between CNDs and MAPT, validated via molecular dynamics simulations. With a zebrafish blood-brain barrier (BBB) model, CNDs were observed to cross the BBB through passive diffusion. CNDs were also found to inhibit the generation of multiple reactive oxygen species, which is an important contributor to AD pathogenesis.

Identifiers

PMID35463198
PMCPMC9030089
OpenAlexW4220927810

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.