Evidence map›Paper›PMID 35463197›Full record

ArticleAmerican heart journal plus : cardiology research and practice2022

Hyperdynamic left ventricular ejection fraction is associated with higher mortality in COVID-19 patients.

Annas Rahman, Max Ruge, Alex Hlepas, Gatha Nair, Joanne Gomez, Jeanne du Fay de Lavallaz, Setri Fugar, Nusrat Jahan, Annabelle Santos Volgman, Kim A Williams and 3 more

Abstract read
In one paragraph

Article in American heart journal plus : cardiology research and practice, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
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  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Annas RahmanDepartment of Internal Medicine, Rush University Medical Center, Chicago, IL, United States of America.
Max RugeDepartment of Internal Medicine, Thomas Jefferson University Hospital, Philadelphia, PA, United States of America.
Alex HlepasDepartment of Internal Medicine, Rush University Medical Center, Chicago, IL, United States of America.
Gatha NairDepartment of Internal Medicine, Rush University Medical Center, Chicago, IL, United States of America.
Joanne GomezDivision of Cardiology, Rush University Medical Center, Chicago, IL, United States of America.
Jeanne du Fay de LavallazDepartment of Internal Medicine, Rush University Medical Center, Chicago, IL, United States of America.
Setri FugarDivision of Cardiology, Rush University Medical Center, Chicago, IL, United States of America.
Nusrat JahanDivision of Cardiology, Rush University Medical Center, Chicago, IL, United States of America.
Annabelle Santos VolgmanDivision of Cardiology, Rush University Medical Center, Chicago, IL, United States of America.
Kim A WilliamsDivision of Cardiology, Rush University Medical Center, Chicago, IL, United States of America.
Anupama RaoDivision of Cardiology, Rush University Medical Center, Chicago, IL, United States of America.
Karolina MarinescuDivision of Cardiology, Rush University Medical Center, Chicago, IL, United States of America.
Tisha SubocDivision of Cardiology, Rush University Medical Center, Chicago, IL, United States of America.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Study objective: To compare the characteristics and outcomes of COVID-19 patients with a hyperdynamic LVEF (HDLVEF) to those with a normal or reduced LVEF. Design: Retrospective study. Setting: Rush University Medical Center. Participants: Of the 1682 adult patients hospitalized with COVID-19, 419 had a transthoracic echocardiogram (TTE) during admission and met study inclusion criteria. Interventions: Participants were divided into reduced (LVEF < 50%), normal (≥50% and <70%), and hyperdynamic (≥70%) LVEF groups. Main outcome measures: LVEF was assessed as a predictor of 60-day mortality. Logistic regression was used to adjust for age and BMI. Results: There was no difference in 60-day mortality between patients in the reduced LVEF and normal LVEF groups (adjusted odds ratio [aOR] 0.87, Conclusion: The presence of hyperdynamic LVEF during a COVID-19 hospitalization was associated with an increased risk of 60-day mortality, the requirement for mechanical ventilation, vasopressors, and intensive care unit.

Indexed as

COVID-19COVID-19, coronavirus disease 2019Heart failureHFpEF, heart failure with preserved ejection fractionHFrEF, heart failure with reduced ejection fractionHyperdynamicICU, intensive care unitLeft ventricular ejection fractionLVEF, left ventricular ejection fractionMACE, major adverse cardiovascular eventsNLVEF, normal left ventricular ejection fractionRLVEF, reduced left ventricular ejection fractionSARS-CoV-2TTE, transthoracic echocardiogram

Identifiers

PMID35463197
PMCPMC9013697

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.