Evidence map›Paper›PMID 35462937›Full record

ArticleFrontiers in pharmacology2022

P2X7 Activation Enhances Lipid Accumulation During Adipocytes Differentiation Through Suppressing the Expression of Sirtuin-3, Sirtuin-5, and Browning Genes.

Chien-Hsieh Chiang, Ching-Yuan Cheng, Yi-Ting Lien, Kuo-Chin Huang, Wan-Wan Lin

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Energy Regulation in Inflammatory Sarcopenia by the Purinergic System.International journal of molecular sciences · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Chien-Hsieh ChiangGraduate Institute of Pharmacology, National Taiwan University College of Medicine, Taipei, Taiwan.
Ching-Yuan ChengGraduate Institute of Pharmacology, National Taiwan University College of Medicine, Taipei, Taiwan.
Yi-Ting LienDepartment of Family Medicine, National Taiwan University Hospital & College of Medicine, Taipei, Taiwan.
Kuo-Chin HuangDepartment of Family Medicine, National Taiwan University Hospital & College of Medicine, Taipei, Taiwan.
Wan-Wan LinGraduate Institute of Pharmacology, National Taiwan University College of Medicine, Taipei, Taiwan.
National Taiwan University Hospital · TWNational Taiwan University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

P2X7 signaling has been explored in adipose tissue because of its potential to promote ATP-activated inflammatory cascades during obesogenic environments. However, limited literature has investigated the role of the P2X7 receptor in lipid metabolism during adipocyte differentiation. This study sought to explore the regulatory roles of P2X7 in adipocytes. This study utilized the

Indexed as

adipocyte differentiationadipogenesisbrowninglipid accumulationP2X7sirtuins

Identifiers

PMID35462937
PMCPMC9019299
OpenAlexW4225565684

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.