Evidence map›Paper›PMID 35462864›Full record

ArticleJournal of nutrition and metabolism2022

Lipoprotein Levels in Early Adulthood and NAFLD in Midlife: The Coronary Artery Risk Development in Young Adults (CARDIA) Study.

Sahil Khanna, John T Wilkins, Hongyan Ning, Norrina B Allen, Cora E Lewis, J Jeffrey Carr, Donald Lloyd-Jones, Lisa B VanWagner

Open access · goldAbstract read
In one paragraph

Article in Journal of nutrition and metabolism, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Sahil KhannaDivision of Gastroenterology & Hepatology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
John T WilkinsDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Hongyan NingDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Norrina B AllenDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Cora E LewisDepartment of Epidemiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
J Jeffrey CarrDepartment of Radiology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Donald Lloyd-JonesDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Lisa B VanWagnerDivision of Gastroenterology & Hepatology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.ORCID https://orcid.org/0000-0002-6264-2573
Northwestern University · USUniversity of Alabama at Birmingham · USVanderbilt University Medical Center · US

Funding

Northwestern University Clinical and Translational Science Institute (NUCATS)KL2TR001424 · NCATS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SHARMA, LEENA · 2015 to 2023
$8.1M
Longitudinal Changes in Pericardial Adiposity and Subclinical AtherosclerosisR01HL098445 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI CARR, JOHN JEFFREY · 2010 to 2013
$4.6M
Implementation science to improve cardiovascular outcomes among liver transplant recipientsK23HL136891 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI VANWAGNER, LISA B · 2017 to 2020
$757k
NCATS NIH HHS KL2 TR001424NHLBI NIH HHS HHSN268201800003INHLBI NIH HHS HHSN268201800004INHLBI NIH HHS HHSN268201800005INHLBI NIH HHS HHSN268201800006INHLBI NIH HHS HHSN268201800007INHLBI NIH HHS K23 HL136891NHLBI NIH HHS R01 HL098445
6 · The paper itself

Abstract

Objective: We evaluated the association of apolipoprotein B (apoB) with low-density lipoprotein cholesterol (LDL-C), non-high-density lipoprotein cholesterol (non-HDL-C), and triglycerides (TG) in early adulthood with concordant/discordant associations and midlife NAFLD. Methods: Participants from the CARDIA study were included ( Results: The Y25 NAFLD prevalence was 10%. The high-tertile TG group (OR 1.87, 95% CI, and 1.30-2.69) and the low- (OR 1.98, 95% CI, and 1.30-3.01) and middle-apoB/TG ratio groups (OR 1.78, 95% CI, and 1.17-2.72) had the greatest odds of midlife NAFLD. Using discordance/concordance analysis, the high-apoB/high-TG group had the highest odds of NAFLD (OR 1.69, 95% CI, and 1.09-2.61) followed by the low-apoB/high-TG group. The high apoB/low TG group had the lowest odds of NAFLD. Conclusions: Among the studied lipid markers in early adulthood, TG levels have the strongest and most consistent association with midlife NAFLD.

Identifiers

PMID35462864
PMCPMC9023214
OpenAlexW4224239631

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.