Evidence map›Paper›PMID 35462704›Full record

ArticleIndian journal of microbiology2022

Cytotoxic Bioxanthracene and Macrocyclic Polyester from Endolichenic Fungus

Chaitrali Shevkar, Ashwini Armarkar, Ramani Weerasinghe, Kasun Maduranga, Komal Pandey, Santosh K Behera, Kiran Kalia, Priyani Paranagama, Abhijeet S Kate

Open access · greenAbstract read
In one paragraph

Article in Indian journal of microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Bioprospecting of Endolichenic FungusIndian journal of microbiology · 2025
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Chaitrali Shevkar *Department of Natural Products, National Institute of Pharmaceutical Education and Research (NIPER) Ahmedabad, Gandhinagar, Gujarat 382355 India.
Ashwini Armarkar *Department of Natural Products, National Institute of Pharmaceutical Education and Research (NIPER) Ahmedabad, Gandhinagar, Gujarat 382355 India.
Ramani WeerasingheDepartment of Chemistry, University of Kelaniya, Dalugama, Kelaniya, 11600 Sri Lanka.
Kasun MadurangaDepartment of Chemistry, University of Kelaniya, Dalugama, Kelaniya, 11600 Sri Lanka.
Komal PandeyDepartment of Natural Products, National Institute of Pharmaceutical Education and Research (NIPER) Ahmedabad, Gandhinagar, Gujarat 382355 India.
Santosh K BeheraDepartment of Biotechnology, National Institute of Pharmaceutical Education and Research, Ahmedabad, Gujarat 382355 India.
Kiran KaliaDepartment of Biotechnology, National Institute of Pharmaceutical Education and Research, Ahmedabad, Gujarat 382355 India.
Priyani ParanagamaDepartment of Chemistry, University of Kelaniya, Dalugama, Kelaniya, 11600 Sri Lanka.
Abhijeet S KateDepartment of Natural Products, National Institute of Pharmaceutical Education and Research (NIPER) Ahmedabad, Gandhinagar, Gujarat 382355 India.ORCID 0000-0003-0500-488X
National Institute of Pharmaceutical Education and Research (NIPER) - Ahmedabad · INUniversity of Kelaniya · LK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lichens are used in folklore medicines across the globe for wound healing and to treat skin disorders and respiratory diseases. They are an intricate symbiosis between fungi and algae with the domination of fungal counterparts. Recent research studies pointed out that yeast is a third major partner in lichens. Endolichenic fungi (ELF) are also a part of this complex miniature ecosystem. The highly competitive environment of lichens compels ELF to produce toxic metabolites which are comparatively less explored for their chemical diversity and use. Here, we investigated 31 ELF isolated from 32 lichens found on mangrove plants at Puttalam Lagoon of Sri Lanka to find cytotoxic molecules by applying LC-UV-HRMS analysis and in vitro bioassays. The studies resulted in the identification of three potent cytotoxic molecules from endolichenic fungi Graphical abstract: Supplementary Information: The online version contains supplementary material available at 10.1007/s12088-021-00994-8.

Indexed as

152G256α-1AnticancerCytotoxicES-242-3Peniazaphilin BTalaromyces pinophilus

Identifiers

PMID35462704
PMCPMC8980127
OpenAlexW4205185947

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.