Evidence map›Paper›PMID 35462701›Full record

ArticleFrontiers in aging neuroscience2022

Quantitative Water Permeability Mapping of Blood-Brain-Barrier Dysfunction in Aging.

Jeremy N Ford, Qihao Zhang, Elizabeth M Sweeney, Alexander E Merkler, Mony J de Leon, Ajay Gupta, Thanh D Nguyen, Jana Ivanidze

Open access · goldAbstract read
In one paragraph

Article in Frontiers in aging neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
6.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 53 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Review
  5. Ocular Solute Movement Direction and Intracranial Clearance via Vitreous Gadolinium-based Contrast Agent MR Imaging: Potential as a Novel Biomarker for Glymphatic Dysfunction.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2026
    Article
  6. Review
  7. Article
  8. Review
  9. Review
  10. The role of autoantibodies in Alzheimer's disease: Pathogenetic connections or epiphenomena?Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Review
  11. Article
  12. Article
  13. PET Imaging of Neurofluids.Neuroimaging clinics of North America · 2025
    Review
  14. Article
  15. Biomarkers of blood-brain barrier and neurovascular unit integrity in human cognitive impairment and dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Review
  16. Article
  17. The interaction between dysfunction of vasculature and tauopathy in Alzheimer's disease and related dementias.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Jeremy N FordDepartment of Radiology, Massachusetts General Hospital, Boston, MA, United States.
Qihao ZhangDepartment of Radiology, Weill Cornell Medicine, New York, NY, United States.
Elizabeth M SweeneyDepartment of Biostatistics, University of Pennsylvania, Philadelphia, PA, United States.
Alexander E MerklerDepartment of Neurology, Weill Cornell Medicine, New York, NY, United States.
Mony J de LeonDepartment of Radiology, Weill Cornell Medicine, New York, NY, United States.
Ajay GuptaDepartment of Radiology, Weill Cornell Medicine, New York, NY, United States.
Thanh D NguyenDepartment of Radiology, Weill Cornell Medicine, New York, NY, United States.
Jana IvanidzeDepartment of Radiology, Weill Cornell Medicine, New York, NY, United States.
Cornell University · USUniversity of Pennsylvania · USWeill Cornell Medicine · US

Funding

Research Education ComponentP30AG066512 · NIA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Mary Sherman Mittelman · 2020 to 2026
$28.4M
NIA NIH HHS P30 AG066512
6 · The paper itself

Abstract

Blood-brain-barrier (BBB) dysfunction is a hallmark of aging and aging-related disorders, including cerebral small vessel disease and Alzheimer's disease. An emerging biomarker of BBB dysfunction is BBB water exchange rate (k

Indexed as

agingarterial spin labelingblood-brain barriercerebral small vessel diseaseglymphatic

Identifiers

PMID35462701
PMCPMC9024318
OpenAlexW4225533703

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.