Evidence map›Paper›PMID 35462611›Full record

ArticleBreast cancer research and treatment2022

Risk factors for psychological morbidity and the protective role of coping self-efficacy in young women with breast cancer early in diagnosis: a national multicentre cohort study.

Doris M Howell, Kelly Metcalfe, Shiying Kong, Joanne Stephen, Ivo A Olivotto, Nancy Baxter, Christine M Friedenreich, Ellen Warner, Mohammed Reza Akbari, Kristine McBain and 2 more

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Breast cancer research and treatment, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
5.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Review
  5. Article
  6. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 2 countries.

Doris M HowellDivision of Supportive Care, Princess Margaret Cancer Research Institute (University Health Network) & Lawrence S. Bloomberg Faculty of Nursing, 610 University Ave. Room 15-617, Toronto, ON, M5G2M9, Canada. doris.howell@uhn.ca.ORCID http://orcid.org/0000-0002-0683-8715
Kelly MetcalfeGenetics, Research and External Affairs, Lawrence S. Bloomberg Faculty of Nursing and Women's College Research Institute, University of Toronto, Toronto, ON, Canada.
Shiying KongDepartment of Surgery, Alberta Health Services, Calgary, AB, Canada.
Joanne StephenClinical Neurosciences Program, Alberta Health Services, Calgary, AB, Canada.
Ivo A OlivottoDivision of Radiation Oncology, Tom Baker Cancer Centre and Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Nancy BaxterDepartment of Surgery, Li Ka Shing Knowledge Institute, St. Michaels Hospital, Toronto, ON, Canada.
Christine M FriedenreichDepartment of Cancer Epidemiology and Prevention Research, Alberta Health Services, Calgary, Alberta, Canada.
Ellen WarnerDepartment of Medical Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.
Mohammed Reza AkbariDivision of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.
Kristine McBainMAP Centre for Urban Health Solutions, Unity Health, Toronto, ON, Canada.
Steven NarodFamilial Breast Cancer Research Unit, Women's College Research Institute and Department of Medicine, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.
May Lynne QuanDepartment of Surgery, University of Calgary, Alberta, ON, Canada.
Alberta Health Services · CAUniversity of Calgary · CAUniversity of Toronto · CASt. Michael's Hospital · CASunnybrook Health Science Centre · CAUniversity Health Network · CAWomen's College Hospital · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeYoung women with breast cancer (YWBC) are an understudied population and there are limited data on risk factors for psychological morbidity early in diagnosis. We examined psychological morbidity (anxiety, depression, stress symptoms), well-being and associated risk factors.

methodsA total of 845 women from a pan-Canadian, multicentre inception cohort study of YWBC (age ≤ 40) who completed Patient Reported Outcome Measures (PROMs) after their initial surgical consultation and prior to surgical or other treatments were included. Multivariate regression analyses identified risk factors (i.e. parenting young children) associated with psychological morbidity and whether coping self-efficacy was protective.

resultsRates of clinically significant anxiety (n = 683, 69.1%) and depression (n = 422, 42.7%) were high but lower for stress symptoms (n = 67, 6.8%). Probability of anxiety was high for women with a previous history of depression (OR 2.02, P = 0.03, CI 1.09-3.74) and working full-time (OR 1.76, P = 0.05 CI 1.02-2.77). Whereas, pre-existing depression (OR 2.91, P = 0.01, CI 1.36-6.01), younger children (age ≤ 10) (OR 1.69, P = 0.05, CI 1.01-2.93), and income > $100,000 (OR 2.06, P = 0.02, CI 1.18-3.64) were risk factors for depression. Coping self-efficacy was protective with a decreased risk of anxiety (OR 0.11, P ≤ 0.01 CI 0.04-0.28), depression (OR 0.03, P ≤ .01, CI 0.01-0.16), stress symptoms (OR 0.17, P ≤ .01, CI 0.04-0.65) and higher psychosocial well-being with a gain of 19.68 points (P < 0.01) for high levels of CSE (> mean plus 1 SD). Those with lower levels of neurosis had less negative outcomes.

conclusionYoung women with breast cancer are vulnerable to psychological morbidity early in diagnosis, particularly those with low coping self-efficacy and may benefit from earlier supportive care.

Indexed as

Breast NeoplasmsSelf EfficacyAdaptation, PsychologicalAnxietyCanadaChildChild, PreschoolCohort StudiesDepressionFemaleHumansMorbidityQuality of LifeRisk FactorsStress, PsychologicalBreast cancerMulticenter cohortPsychological morbidityYoung women

Identifiers

PMID35462611
OpenAlexW4224326647

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.