ArticleNeuroradiology2022
Middle cingulate cortex function contributes to response to non-steroidal anti-inflammatory drug in cervical spondylosis patients: a preliminary resting-state fMRI study.
Article in Neuroradiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 9 papers, 2 of them syntheses that pooled it.
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Who cites it
9 citing papers in PubMed, 2 syntheses or guidelines pooled it, 15 citations in OpenAlex.
- Abnormalities of brain structure and function in cervical spondylosis: a multi-modal voxel-based meta-analysis.Frontiers in neuroscience · 2024Pooled it
- Meta-analysis of resting-state fMRI in cervical spondylosis patients using AES-SDM.Frontiers in neurology · 2024Pooled it
- Altered functional connectivity density in the prefrontal-limbic-visual networks of vestibular migraine.Scientific reports · 2026Article
- Peripheral inflammation and central sensitization associated with postoperative pain following arthroscopy surgery in rotator cuff injury.La Radiologia medica · 2026Article
- Smoking and High-Altitude Exposure Affect Intrinsic Neural Activity: A fMRI Study of Interactive Effects.Addiction biology · 2025Article
- Changes of regional brain activity following Tuina therapy for patients with painful cervical spondylosis: a resting-state fMRI study.Frontiers in neurology · 2024Article
- Preoperative pain hypersensitivity is associated with axial pain after posterior cervical spinal surgeries in degenerative cervical myelopathy patients: a preliminary resting-state fMRI study.Insights into imaging · 2023Article
- Moxibustion for primary dysmenorrhea: A resting-state functional magnetic resonance imaging study exploring the alteration of functional connectivity strength and functional connectivity.Frontiers in neuroscience · 2022Article
- Resilience mediates the influence of hope, optimism, social support, and stress on anxiety severity among Chinese patients with cervical spondylosis.Frontiers in psychiatry · 2022Article
Corrections and comments
- Erratum issued
Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectiveCervical spondylosis (CS) is often accompanied by persistent cervical pain, and psychological complications including depression and anxiety, which aggravate pain. Past studies have revealed brain alterations in chronic pain patients. However, the cortical mechanism for NSAID (non-steroidal anti-inflammatory drug) responders relative to non-responders is still lacking. Therefore, we aimed to investigate the brain functional differences between responders to NSAID relative to non-responders using amplitude of low-frequency fluctuation (ALFF) and dynamic functional connectivity variance (DFCV). To our knowledge, our study is the first to investigate the DFCV in CS patients. MATERIALS AND
methodsWe first explored the differences in psychological inventories in CS patients who respond to NSAID vs non-responders. The voxel-wise ALFF was calculated and compared between CS patients and healthy controls. The ALFF within the resultant clusters were extracted and compared between responders and non-responders. DFCV among the resulting clusters was compared in responders vs non-responders.
resultsWe found that (1) compared to responders, non-responders exhibited higher levels of anxiety and depression; (2) relative to healthy controls, CS patients exhibited altered ALFF within the middle cingulate cortice (MCC), cerebellum, and middle frontal gyrus (MFG); (3) moreover, compared with responders, non-responders exhibited lower ALFF within MCC; furthermore, non-responders also exhibited increased DFCV between MCC and cerebellum, and between MCC and MFG.
conclusionOur data indicate that psychological comorbidities (e.g., anxiety) influence response to NSAID in CS patients. Relative to NSAID responders, non-responders had altered MCC function, which may be associated with anxiety in CS patients.
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