Evidence map›Paper›PMID 35462561›Full record

Trial reportBritish journal of cancer2022

Sodium accumulation in breast cancer predicts malignancy and treatment response.

Andrew D James, Theresa K Leslie, Joshua D Kaggie, Laura Wiggins, Lewis Patten, John Murphy O'Duinn, Swen Langer, Marie-Christine Labarthe, Frank Riemer, Gabrielle Baxter and 4 more

Open access · hybridAbstract readRandomized Controlled Trial
In one paragraph

Trial report in British journal of cancer, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
6.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 46 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Monitoring Pharmacological Treatment of Breast Cancer with MRI.Current issues in molecular biology · 2025
    Review
  7. Article
  8. Review
  9. Article
  10. Metal Ion Signaling in Biomedicine.Chemical reviews · 2025
    Review
  11. Review
  12. Article
  13. A novel NaOncogene · 2024
    Article
  14. European radiology experimental · 2024
    Article
  15. Article
  16. Disrupting NaCancer & metabolism · 2024
    Article
  17. Review
  18. Article
  19. Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 2 countries.

Andrew D JamesDepartment of Biology, University of York, York, UK.ORCID http://orcid.org/0000-0002-2432-5948
Theresa K LeslieDepartment of Biology, University of York, York, UK.
Joshua D KaggieDepartment of Radiology & NIHR Cambridge Biomedical Research Centre, University of Cambridge, Cambridge, UK.
Laura WigginsDepartment of Biology, University of York, York, UK.
Lewis PattenDepartment of Mathematics, University of York, York, UK.
John Murphy O'DuinnDepartment of Chemistry, University of York, York, UK.
Swen LangerBioscience Technology Facility, Department of Biology, University of York, York, UK.
Marie-Christine LabartheDepartment of Physics, University of York, York, UK.
Frank RiemerMohn Medical Imaging and Visualization Centre, Haukeland University Hospital Bergen, Bergen, Norway.
Gabrielle BaxterDepartment of Radiology & NIHR Cambridge Biomedical Research Centre, University of Cambridge, Cambridge, UK.
Mary A McLeanDepartment of Radiology & NIHR Cambridge Biomedical Research Centre, University of Cambridge, Cambridge, UK.
Fiona J GilbertDepartment of Radiology & NIHR Cambridge Biomedical Research Centre, University of Cambridge, Cambridge, UK.
Aneurin J KennerleyYork Biomedical Research Institute, University of York, York, UK.
William J BrackenburyDepartment of Biology, University of York, York, UK. william.brackenbury@york.ac.uk.ORCID http://orcid.org/0000-0001-6882-3351
University of York · GBUniversity of Cambridge · GBHaukeland University Hospital · NO

Funding

Breast Cancer Now 2015NOVPHD572Cancer Research UK 25922Cancer Research UK 30380Department of Health
6 · The paper itself

Abstract

backgroundBreast cancer remains a leading cause of death in women and novel imaging biomarkers are urgently required. Here, we demonstrate the diagnostic and treatment-monitoring potential of non-invasive sodium (

methodsFemale Rag2

results

conclusionsOrthotopic breast cancer models exhibit elevated tumour [Na

Indexed as

Breast NeoplasmsSodiumAnimalsContrast MediaDiffusion Magnetic Resonance ImagingFemaleHumansMagnetic Resonance ImagingMiceContrast MediaSodium

Identifiers

PMID35462561
PMCPMC9296657
OpenAlexW4226174991

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.