Evidence map›Paper›PMID 35462473›Full record

ArticleActa biochimica et biophysica Sinica2022

Ch25h and 25-HC prevent liver steatosis through regulation of cholesterol metabolism and inflammation.

Yaqiong Wang, Jin Zhang, Jie Chen, Dan Wang, Yang Yu, Pei Qiu, Qiqi Wang, Wenbao Zhao, Zhao Li, Ting Lei

Open access · diamondAbstract read
In one paragraph

Article in Acta biochimica et biophysica Sinica, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. 25-Hydroxycholesterol in health and diseases.Journal of lipid research · 2024
    Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Yaqiong WangDepartment of Pathology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an 710061, China.
Jin ZhangCardiovascular Research Center, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an 710061, China, and.
Jie ChenDepartment of Pathology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an 710061, China.
Dan WangDepartment of Pathology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an 710061, China.
Yang YuDepartment of Pathology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an 710061, China.
Pei QiuDepartment of Pathology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an 710061, China.
Qiqi WangDepartment of Pathology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an 710061, China.
Wenbao ZhaoDepartment of Pathology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an 710061, China.
Zhao LiCardiovascular Research Center, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an 710061, China, and.
Ting LeiDepartment of Pathology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an 710061, China.
Xi'an Jiaotong University · CNShaanxi Blood Center · CNShanxi Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Non-alcoholic fatty liver disease (NAFLD) is currently the most prevalent metabolic disorder all over the world, and lipid metabolic disorders and inflammation are closely associated and contribute to the pathogenesis of NAFLD. Cholesterol 25-hydroxylase (Ch25h) and its product, 25-hydroxycholesterol (25-HC), play important roles in cholesterol homeostasis and inflammation, but whether Ch25h and 25-HC are involved in NAFLD remains uncertain. In this study, we use

Indexed as

InflammasomesNon-alcoholic Fatty Liver DiseaseAnimalsCholesterolDiet, High-FatHumansInflammationLipid MetabolismLiverLiver X ReceptorsMiceMice, KnockoutNLR Family, Pyrin Domain-Containing 3 ProteinSteroid HydroxylasesSterol Regulatory Element Binding Protein 1TriglyceridesCholesterolcholesterol 25-hydroxylaseInflammasomesLiver X ReceptorsNLR Family, Pyrin Domain-Containing 3 ProteinSteroid HydroxylasesSterol Regulatory Element Binding Protein 1Triglycerides25-HCCh25hhigh fat dietLXRαNLRP3 inflammasome

Identifiers

PMID35462473
PMCPMC9828056
OpenAlexW4224236598

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.