Evidence map›Paper›PMID 35462298›Full record

ArticleRespiratory medicine2022

Characteristics and outcomes of ambulatory patients with suspected COVID-19 at a respiratory referral center.

Vamsi P Guntur, Brian D Modena, Laurie A Manka, Jared J Eddy, Shu-Yi Liao, Nir M Goldstein, Pearlanne Zelarney, Carrie A Horn, Rebecca C Keith, Barry J Make and 2 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Respiratory medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Vamsi P GunturDivision of Pulmonary, Critical Care, and Sleep Medicine, National Jewish Health, Denver, CO, USA; The NJH Cohen Family Asthma Institute, National Jewish Health, Denver, CO, USA; Division of Pulmonary Sciences and Critical Care Medicine, School of Medicine, University of Colorado, Denver, CO, USA. Electronic address: Gunturv@njhealth.org.
Brian D ModenaModena Allergy & Asthma, La Jolla, CA, USA.
Laurie A MankaDivision of Pulmonary, Critical Care, and Sleep Medicine, National Jewish Health, Denver, CO, USA; The NJH Cohen Family Asthma Institute, National Jewish Health, Denver, CO, USA.
Jared J EddyDivision of Mycobacterial and Respiratory Infections, National Jewish Health, Denver, CO, USA.
Shu-Yi LiaoDivision of Pulmonary, Critical Care, and Sleep Medicine, National Jewish Health, Denver, CO, USA.
Nir M GoldsteinDivision of Pulmonary, Critical Care, and Sleep Medicine, National Jewish Health, Denver, CO, USA.
Pearlanne ZelarneyResearch Informatics Services, National Jewish Health, Denver, CO, USA.
Carrie A HornDivision of Hospital & Internal Medicine, National Jewish Health, Denver, CO, USA.
Rebecca C KeithDivision of Pulmonary, Critical Care, and Sleep Medicine, National Jewish Health, Denver, CO, USA; Division of Pulmonary Sciences and Critical Care Medicine, School of Medicine, University of Colorado, Denver, CO, USA.
Barry J MakeDivision of Pulmonary, Critical Care, and Sleep Medicine, National Jewish Health, Denver, CO, USA; Division of Pulmonary Sciences and Critical Care Medicine, School of Medicine, University of Colorado, Denver, CO, USA.
Irina PetracheDivision of Pulmonary, Critical Care, and Sleep Medicine, National Jewish Health, Denver, CO, USA; Division of Pulmonary Sciences and Critical Care Medicine, School of Medicine, University of Colorado, Denver, CO, USA.
Michael E WechslerDivision of Pulmonary, Critical Care, and Sleep Medicine, National Jewish Health, Denver, CO, USA; The NJH Cohen Family Asthma Institute, National Jewish Health, Denver, CO, USA; Division of Pulmonary Sciences and Critical Care Medicine, School of Medicine, University of Colorado, Denver, CO, USA.
National Jewish Health · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

rationaleSARS-CoV-2 continues to cause a global pandemic and management of COVID-19 in outpatient settings remains challenging.

objectiveWe sought to describe characteristics of patients with chronic respiratory disease (CRD) experiencing symptoms consistent with COVID-19, who were seen in a novel Acute Respiratory Clinic, prior to widely available testing, emergence of variants, COVID-19 vaccination, and post-vaccination (breakthrough) SARS-CoV-2 infections.

methodsRetrospective electronic medical record data were analyzed from 907 adults with presumed COVID-19 seen between March 16, 2020 and January 7, 2021. Data included demographics, comorbidities, medications, vital signs, laboratory tests, pulmonary function tests, patient disposition, and co-infections. The overdispersed data (aod) R package was used to create a logit model using COVID-19 diagnosis by PCR as the dichotomous outcome variable. Univariate, conventional multivariate and elastic net machine learning were used to analyze data.

resultsMale gender, elevated baseline temperature, and respiratory rate predicted COVID-19 diagnosis. Eosinopenia, neutrophilia, and lymphocytosis were also associated with COVID-19 diagnosis. However, asthma and COPD diagnoses were not associated with SARS-CoV-2 PCR positive test. Male gender, low oxygen saturation, and lower forced expiratory volume in 1 s (FEV

conclusionsCRD patients with acute respiratory symptoms in the ambulatory setting were more likely to have COVID-19 if male, febrile and tachypneic. Patients with lower pre-morbid FEV

Indexed as

COVID-19SARS-CoV-2AdultCOVID-19 TestingCOVID-19 VaccinesFeverHumansMaleReferral and ConsultationRetrospective StudiesCOVID-19 VaccinesAmbulatory respiratory infectionsClinical predictionCOVID-19

Identifiers

PMID35462298
PMCPMC8986541
OpenAlexW4225319388

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.