Evidence map›Paper›PMID 35462024›Full record

ReviewThe Canadian journal of cardiology2022

Drugs of Misuse: Focus on Vascular Dysfunction.

Holly R Middlekauff, Ziva D Cooper, Sasha B Strauss

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The Canadian journal of cardiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 33 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Holly R MiddlekauffDivision of Cardiology, Department of Medicine, UCLA David Geffen School of Medicine, Los Angeles, California, USA; Department of Physiology, UCLA David Geffen School of Medicine, Los Angeles, California, USA. Electronic address: hmiddlekauff@mednet.ucla.edu.
Ziva D CooperUCLA Cannabis Research Initiative, Jane and Terry Semel Institute for Neuroscience and Human Behaviour, Department of Psychiatry and Biobehavioral Sciences, UCLA David Geffen School of Medicine, Los Angeles, California, USA; Department of Anesthesiology and Perioperative Medicine, UCLA David Geffen School of Medicine, Los Angeles, California, USA.
Sasha B StraussAnderson School of Management, University of California, Los Angeles, California, USA; Marshall School of Business, University of Southern California, Los Angeles, California, USA; Paul Merage School of Business, University of California, Irvine, California, USA.
University of California, Los Angeles · USUniversity of Southern California · US

Funding

Sex-dependent effects of cannabis: Assessing abuse-related and pharmacokinetic differences between men and womenR01DA047296 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI COOPER, ZIVA D · 2019 to 2024
$3.5M
NIDA NIH HHS R01 DA047296
6 · The paper itself

Abstract

Common drugs of misuse, including cannabis, opioids, stimulants, alcohol, and anabolic steroids, have strikingly disparate acute and chronic vascular effects, leading to a wide range of clinical cardiovascular presentations. Acute cannabis smoking has been associated with increased risk for myocardial infarction and ischemic stroke in otherwise healthy young people. However, it remains uncertain if people who exclusively smoke cannabis have increased risk for accelerated atherosclerosis similar to that found in people who exclusively smoke tobacco cigarettes. Cocaine and methamphetamines, both stimulants, increase risk for stroke, myocardial infarction, aortic dissection, and accelerated atherosclerosis, but only methamphetamine use is strongly linked to pulmonary hypertension. Chronic alcohol use is strongly associated with chronic hypertension and hemorrhagic stroke, but perhaps confers a lower risk for myocardial infarction. Finally, anabolic steroid use, presumably through adverse effects on circulating lipids and the hematopoietic system, is associated with increased risk for accelerated atherosclerosis and myocardial infarction. Physicians, especially cardiologists, emergency medicine, and internal medicine physicians, should be familiar with the short- and long-term vascular consequences of use of these substances, thereby ensuring appropriate, specific, and informed counselling and treatment.

Indexed as

AtherosclerosisCannabisCentral Nervous System StimulantsMarijuana SmokingMyocardial InfarctionAdolescentHumansSmokeCentral Nervous System StimulantsSmoke

Identifiers

PMID35462024
PMCPMC9474615
OpenAlexW4224219705

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.