Evidence map›Paper›PMID 35461614›Full record

ArticleKidney international2022

Regulation of T- and B-cell interactions determines the clinical phenotype associated with donor-specific antibodies.

Sumoyee Basu, Anthony Dorling

Abstract readComment
PubMed Publisher
In one paragraph

Article in Kidney international, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Activation and Regulation of Indirect Alloresponses in Transplanted Patients With Donor Specific Antibodies and Chronic Rejection.Transplant international : official journal of the European Society for Organ Transplantation · 2024
    Review
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Sumoyee BasuCentre for Nephrology, Urology and Transplantation, Department of Inflammation Biology, King's College London, Guy's Hospital, London, UK.
Anthony DorlingCentre for Nephrology, Urology and Transplantation, Department of Inflammation Biology, King's College London, Guy's Hospital, London, UK. Electronic address: anthony.dorling@kcl.ac.uk.
Guy's Hospital · GB

Funding

Medical Research Council MR/J006742/1Medical Research Council MR/T006560/1
6 · The paper itself

Abstract

The cellular mechanisms that regulate donor-specific antibody formation and antibody-mediated rejection remain unknown. In this issue, Louis et al. report that specific T-regulatory cell and B-regulatory transitional cell subsets are concomitantly diminished in patients with donor-specific antibody and consequent antibody-mediated rejection and advance alterations in specific cytokines and costimulatory molecules as important mechanisms by which these cells may suppress donor-specific antibody formation and, independently, progression to antibody-mediated rejection.

Indexed as

Graft RejectionKidney TransplantationAntibodiesCell CommunicationHumansPhenotypeTissue DonorsAntibodies

Identifiers

PMID35461614
OpenAlexW4224243804

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.