ArticleThe Journal of the Acoustical Society of America2022
Identifying and overcoming limitations with in situ calibration beads for quantitative ultrasound.
Article in The Journal of the Acoustical Society of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- Assessing the benefits of using plane wave compounding when estimating backscatter coefficients with an in situ bead as a calibration target.The Journal of the Acoustical Society of America · 2026Article
- Toward Real-Time Backscatter Coefficient Estimation Incorporating the U-Net Segmentation and an In Vivo Reference Target.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2025Article
- Underlying factors that affect ultrasound conspicuity of breast biopsy markers: an exploratory study.Translational breast cancer research : a journal focusing on translational research in breast cancer · 2025Article
- In Vivo Validation of an In Situ Calibration Bead as a Reference for Backscatter Coefficient Calculation.Ultrasound in medicine & biology · 2024Article
- Spectral-based Quantitative Ultrasound Imaging Processing Techniques: Comparisons of RF Versus IQ Approaches.Ultrasonic imaging · 2024Article
- Quantitative Ultrasound: Experimental Implementation.Advances in experimental medicine and biology · 2023Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Ensuring the consistency of spectral-based quantitative ultrasound estimates in vivo necessitates accounting for diffraction, system effects, and propagation losses encountered in the tissue. Accounting for diffraction and system effects is typically achieved through planar reflector or reference phantom methods; however, neither of these is able to account for the tissue losses present in vivo between the ultrasound probe and the region of interest. In previous work, the feasibility of small titanium beads as in situ calibration targets (0.5-2 mm in diameter) was investigated. In this study, the importance of bead size for the calibration signal, the role of multiple echoes coming from the calibration bead, and sampling of the bead signal laterally through beam translation were examined. This work demonstrates that although the titanium beads naturally produce multiple reverberant echoes, time-windowing of the first echo provides the smoothest calibration spectrum for backscatter coefficient calculation. When translating the beam across the bead, the amplitude of the echo decreases rapidly as the beam moves across and past the bead. Therefore, to obtain consistent calibration signals from the bead, lateral interpolation is needed to approximate signals coming from the center of the bead with respect to the beam.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.