Evidence map›Paper›PMID 35461300›Full record

ArticleTrials2022

An adaptive design to screen, treat, and retain people with opioid use disorders who use methamphetamine in methadone clinics (STAR-OM): study protocol of a clinical trial.

Le Minh Giang, Nguyen Thu Trang, Nguyen Bich Diep, Dao Thi Dieu Thuy, Dinh Thanh Thuy, Han Dinh Hoe, Hoang Thi Hai Van, Thai Thanh Truc, Hoa H Nguyen, Nguyen Ly Lai and 9 more

2 registry-linked trialsOpen access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04706624 nacompletednot on this map

Screen, Treat and Retain Meth-using People With Opioid Use Disorders at Methadone Clinics

TypeinterventionalSponsorHanoi Medical UniversityRan2021 to 2025Enrolled667ConditionsMethamphetamine Abuse, Opioid-use Disorder, HIV SeropositivityArmsContingency management (12 weeks), Contingency management (6 weeks), SMS reminders, Matrix only, Matrix + Contingency management
NCT07121296 naactive not recruitingnot on this mapstarted 2025, after this paper: background citation

Screen, Treat and Retain People With Primary Meth Use Disorder at MMT Clinics

TypeinterventionalSponsorHanoi Medical UniversityRan2025 to 2025Enrolled60ConditionsMethamphetamine Use DisorderArmsContingency management for substance use, Contingency management for attendance, Group-based Matrix counseling, Individual-based Matrix counseling
3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 8 citations in OpenAlex.

  1. Trial
  2. Article
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  4. Article
  5. Article
  6. Perspectives on addiction-related problems in Vietnam.Addiction (Abingdon, England) · 2026
    Review
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  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 4 institutions in 2 countries.

Le Minh GiangCentre for Training and Research on Substance use and HIV, Hanoi Medical University, Hanoi, Vietnam.
Nguyen Thu TrangCentre for Training and Research on Substance use and HIV, Hanoi Medical University, Hanoi, Vietnam. trangthu@hmu.edu.vn.
Nguyen Bich DiepCentre for Training and Research on Substance use and HIV, Hanoi Medical University, Hanoi, Vietnam.
Dao Thi Dieu ThuyCentre for Training and Research on Substance use and HIV, Hanoi Medical University, Hanoi, Vietnam.
Dinh Thanh ThuyCentre for Training and Research on Substance use and HIV, Hanoi Medical University, Hanoi, Vietnam.
Han Dinh HoeCentre for Training and Research on Substance use and HIV, Hanoi Medical University, Hanoi, Vietnam.
Hoang Thi Hai VanGlobal Health Department, Hanoi Medical University, Hanoi, Vietnam.
Thai Thanh TrucFaculty of Public Health, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam.
Hoa H NguyenUniversity of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam.
Nguyen Ly LaiSouth Vietnam HIV and Addiction Technology Transfer Center, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam.
Pham Thi Dan LinhSouth Vietnam HIV and Addiction Technology Transfer Center, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam.
Vu Thi Tuong ViSouth Vietnam HIV and Addiction Technology Transfer Center, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam.
Cathy J RebackFriends Research Institute, Friends Community Center, Center for HIV Identification, Prevention and Treatment Services, University of California, Los Angeles, Los Angeles, USA.
Arleen LeibowitzDepartment of Public Policy, Luskin School of Public Affairs, University of California, Los Angeles, Los Angeles, USA.
Li LiDepartment of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, Los Angeles, USA.
Chunqing LinDepartment of Psychiatry and Biobehavioral Sciences, Jane & Terry Semel Institute for Neuroscience & Human Behavior, University of California, Los Angeles, Los Angeles, USA.
Michael LiCenter for Behavioral and Addiction Medicine, Department of Family Medicine, University of California, Los Angeles, Los Angeles, USA.
Do Van DungFaculty of Public Health, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam.
Steve ShoptawCenter for Behavioral and Addiction Medicine, Department of Family Medicine, University of California, Los Angeles, Los Angeles, USA.
Hanoi Medical University · VNHo Chi Minh City Medicine and Pharmacy University · VNUniversity of California, Los Angeles · USFriends Research Institute · US

Funding

UCLA Rapid, Relevant, Rigorous Implementation Science HubP30MH058107 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Nina Thawata Harawa · 1997 to 2026
$53.5M
Screen, Treat and Retain People with Primary Meth Use Disorder at MMT Clinics (STAR-OM+)R01DA050486 · NIDA · HANOI MEDICAL UNIVERSITY · PI LE, GIANG M, SHOPTAW, STEVEN J · 2020 to 2024
$2.3M
Trajectories of socially regulated gene expression, methamphetamine use, and viral load among HIV-positive men who have sex with men (MSM) receiving contingency managementK01DA051329 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LI, MICHAEL JONATHAN · 2021 to 2025
$947k
NIDA NIH HHS K01 DA051329NIDA NIH HHS R01 DA050486NIDA NIH HHS R01DA050486NIMH NIH HHS P30 MH058107
6 · The paper itself

Abstract

backgroundMethamphetamine use could jeopardize the current efforts to address opioid use disorder and HIV infection. Evidence-based behavioral interventions (EBI) are effective in reducing methamphetamine use. However, evidence on optimal combinations of EBI is limited. This protocol presents a type-1 effectiveness-implementation hybrid design to evaluate the effectiveness, cost-effectiveness of adaptive methamphetamine use interventions, and their implementation barriers in Vietnam.

methodDesign: Participants will be first randomized into two frontline interventions for 12 weeks. They will then be placed or randomized to three adaptive strategies for another 12 weeks. An economic evaluation and an ethnographic evaluation will be conducted alongside the interventions.

participantsWe will recruit 600 participants in 20 methadone clinics. ELIGIBILITY CRITERIA: (1) age 16+; (2) Alcohol, Smoking and Substance Involvement Screening Test (ASSIST) scores ≥ 10 for methamphetamine use or confirmed methamphetamine use with urine drug screening; (3) willing to provide three pieces of contact information; and (4) having a cell phone. OUTCOMES: Outcomes are measured at 13, 26, and 49 weeks and throughout the interventions. Primary outcomes include the (1) increase in HIV viral suppression, (2) reduction in HIV risk behaviors, and (3) reduction in methamphetamine use. COVID-19 response: We developed a response plan for interruptions caused by COVID-19 lockdowns to ensure data quality and intervention fidelity. DISCUSSION: This study will provide important evidence for scale-up of EBIs for methamphetamine use among methadone patients in limited-resource settings. As the EBIs will be delivered by methadone providers, they can be readily implemented if the trial demonstrates effectiveness and cost-effectiveness.

trial registrationClinicalTrials.gov NCT04706624. Registered on 13 January 2021. https://clinicaltrials.gov/ct2/show/NCT04706624.

Indexed as

Amphetamine-Related DisordersHIV InfectionsMethamphetamineOpioid-Related DisordersAdolescentCOVID-19HumansMethadoneRandomized Controlled Trials as TopicMethadoneMethamphetamineAmphetamine-type stimulantsMethadoneMethamphetamineOpioid substitutionRandomized controlled trialVietnam

Identifiers

PMID35461300
PMCPMC9034071
OpenAlexW4225314908

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.