ArticleBMC genomics2022
Effects of growth years on ginsenoside biosynthesis of wild ginseng and cultivated ginseng.
Article in BMC genomics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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25 citing papers in PubMed, 46 citations in OpenAlex.
- Chromosome-level genome of wild-simulated Panax ginseng identifies SNP markers for germplasm and medicinal quality evaluation.Journal of advanced research · 2026Article
- Multivariate Statistical Evaluation of Ginseng Quality and Antioxidant Activity.Molecules (Basel, Switzerland) · 2026Article
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- Contemporary perceptions of ginseng among individuals with health needs: A nationwide questionnaire survey.Journal of ginseng research · 2026Article
- Contemporary utilization of ginseng among individuals with health needs: A nationwide questionnaire survey.Journal of ginseng research · 2026Article
- Pro-Apoptotic and Anti-EMT Activity of Wild Ginseng Adventitious Root Extract in MDA-MB-231 TNBC Cells: Association with GSK-3β/β-Catenin Signaling.Pharmaceuticals (Basel, Switzerland) · 2026Article
- Comparative mitochondrial genome analysis of Panax ginseng reveals structural variation and genetic diversity.Scientific reports · 2025Article
- Comparative Study of Wild and CultivatedMolecules (Basel, Switzerland) · 2025Article
- Multi-omics dissection of metabolic and transcriptional regulation underlying fruit maturation in Panax ginseng.BMC plant biology · 2025Article
- Phylogenetic Analysis and Expression Patterns of Triterpenoid Saponin Biosynthesis Genes in 19 Araliaceae Plants.International journal of molecular sciences · 2025Article
- Comprehensive analysis of the flavor volatiles and quality characteristics of ginseng products via GC × GC-TOF-MS, aroma profiles and multivariate statistics.Frontiers in nutrition · 2025Article
- Identifying hub genes and key functional modules in leaf tissue of Populus species based on WGCNA.Genetica · 2024Article
- Ginseng and ginseng byproducts for skincare and skin health.Journal of ginseng research · 2024Review
- Integrated Analysis of Ginsenoside Content and Biomarker Changes in Processed Ginseng: Implications for Anti-Cancer Mechanisms.Foods (Basel, Switzerland) · 2024Article
- Recent trends in ginseng research.Journal of natural medicines · 2024Review
- Comparative Metabolome and Transcriptome Analyses Reveal Differential Enrichment of Metabolites with Age inPlants (Basel, Switzerland) · 2024Article
- Endophytic fungi of Panax sokpayensis produce bioactive ginsenoside Compound K in flask fermentation.Scientific reports · 2024Article
- Increasing the Amounts of Bioactive Components in American Ginseng (Foods (Basel, Switzerland) · 2024Article
- Article
- Genome-Wide Identification and Expression Analysis of Auxin Response Factor (ARF) Gene Family inPlants (Basel, Switzerland) · 2023Article
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6 authors at 1 institution in 1 country.
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Abstract
backgroundGinsenoside, as the main active substance in ginseng, has the function of treating various diseases. However, the ginsenosides content of cultivated ginseng is obviously affected by the growth years, but the molecular mechanism is not clear. In addition, there are significant differences in morphology and physiology between wild ginseng and cultivated ginseng, and the effect of growth years on ginsenoside synthesis not yet understood in wild ginseng.
resultsTranscriptome sequencing on the roots, stems and leaves of cultivated ginseng and wild ginseng with different growth years was performed in this study, exploring the effect of growth years on gene expression in ginseng. The number of differentially expressed genes (DEGs) from comparison groups in cultivated ginseng was higher than that in wild ginseng. The result of weighted gene co-expression network analysis (WGCNA) showed that growth years significantly affected the gene expression of Mitogen-activated protein kinases (MAPK) signaling pathway and terpenoid backbone biosynthesis pathway in cultivated ginseng, but had no effects in wild ginseng. Furthermore, the growth years had significant effects on the genes related to ginsenoside synthesis in cultivated ginseng, and the effects were different in the roots, stems and leaves. However, it had little influence on the expression of genes related to ginsenoside synthesis in wild ginseng. Growth years might affect the expression of genes for ginsenoside synthesis by influencing the expression of these transcription factors (TFs), like my elob lastosis (MYB), NAM, ATAF1 and 2, and CUC2 (NAC), APETALA2/ethylene-responsive factor (AP2/ERF), basic helix-loop-helix (bHLH) and WRKY, etc., thereby affecting the content of ginsenosides.
conclusionsThis study complemented the gaps in the genetic information of wild ginseng in different growth periods and helped to clarify the potential mechanisms of the effect of growth years on the physiological state in wild ginseng and cultivated ginseng, which also provided a new insight into the mechanism of ginsenoside regulation.
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