Evidence map›Paper›PMID 35460882›Full record

ArticleAnnals of hepatology

Loneliness in adults awaiting liver transplantation at 7 U.S. transplant centers.

Kacey A Berry, Dorothea Kent, Srilakshmi Seetharaman, Randi Wong, Yara Mohamad, Frederick Yao, Maria Nunez-Duarte, Sharad I Wadhwani, Brian J Boyarsky, Robert S Rahimi and 9 more

Registry-linked trialOpen access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of hepatology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03228290 (Functional Assessment in Liver Transplant Candidates), which is not on this map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03228290 recruitingnot on this map

Functional Assessment in Liver Transplant Candidates (FrAILT) Study

TypeobservationalSponsorUniversity of California, San FranciscoRan2011 to 2030Enrolled5,000ConditionsEnd Stage Liver Disease
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Review
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 8 institutions in 1 country.

Kacey A BerryDepartment of Medicine, Division of Gastroenterology and Hepatology, University of California San Francisco, San Francisco, CA, United States.
Dorothea KentDepartment of Medicine, Division of Gastroenterology and Hepatology, University of California San Francisco, San Francisco, CA, United States.
Srilakshmi SeetharamanDepartment of Medicine, Division of Gastroenterology and Hepatology, University of California San Francisco, San Francisco, CA, United States.
Randi WongDepartment of Medicine, Division of Gastroenterology and Hepatology, University of California San Francisco, San Francisco, CA, United States.
Yara MohamadDepartment of Medicine, Division of Gastroenterology and Hepatology, University of California San Francisco, San Francisco, CA, United States.
Frederick YaoDepartment of Medicine, Division of Gastroenterology and Hepatology, University of California San Francisco, San Francisco, CA, United States.
Maria Nunez-DuarteJohns Hopkins University, Baltimore, MD, United States.
Sharad I WadhwaniDepartment of Medicine, Division of Gastroenterology and Hepatology, University of California San Francisco, San Francisco, CA, United States.
Brian J BoyarskyJohns Hopkins University, Baltimore, MD, United States.
Robert S RahimiBaylor University Medical Center at Dallas, Dallas, TX, United States.
Andres Duarte-RojoUniversity of Pittsburgh Medical Center, Pittsburgh, PA, United States.
Matthew R KappusDuke University School of Medicine, Durham, NC, United States.
Michael L VolkLoma Linda University Adventist Health Sciences Center, Loma Linda, CA, United States.
Daniela P LadnerNorthwestern University Feinberg School of Medicine, Chicago, IL, United States.
Dorry L SegevJohns Hopkins University, Baltimore, MD, United States.
Mara McAdams-DeMarcoJohns Hopkins University, Baltimore, MD, United States.
Elizabeth C VernaColumbia University Irving Medical Center, New York, NY, United States.
Daniel R GangerNorthwestern University Feinberg School of Medicine, Chicago, IL, United States.
Jennifer C LaiDepartment of Medicine, Division of Gastroenterology and Hepatology, University of California San Francisco, San Francisco, CA, United States. Electronic address: jennifer.lai@ucsf.edu.
University of California, San Francisco · USJohns Hopkins University · USNorthwestern University · USBaylor University Medical Center · USColumbia University Irving Medical Center · USDuke University · USLoma Linda University Health Care · USUniversity of Pittsburgh Medical Center · US

Funding

UCSF Liver Core CenterP30DK026743 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Holger Willenbring · 1986 to 2026
$30.7M
Institutional Career Development Core SupplementKL2TR001870 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KANAYA, ALKA M., SARKAR, URMIMALA · 2016 to 2025
$19.7M
NRSA Training CoreTL1TR001871 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KANAYA, ALKA M., SOMSOUK, MA · 2016 to 2025
$10.1M
The spectrum of cognitive impairment including Alzheimer’s Disease and Related Dementias after liver transplantationR01AG059183 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Jennifer C. Lai · 2018 to 2026
$9.9M
The Organoid and Cell Culture CoreP30DK132710 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Robert F. Schwabe · 2022 to 2026
$7.2M
Patient Oriented Research in Solid Organ TransplantationK24AI144954 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI SEGEV, DORRY L. · 2020 to 2024
$956k
Patient Oriented Research in Kidney Disease and Transplant SurgeryK24DK101828 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI SEGEV, DORRY L. · 2014 to 2018
$922k
Frailty and Functional Status in Older Liver Transplant PatientsK23AG048337 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LAI, JENNIFER C. · 2014 to 2018
$911k
Aggressive Organ Procurement Organization Report Cards to Safely Increase Kidney TransplantationF32DK124941 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI BOYARSKY, BRIAN · 2020 to 2020
$81k
NCATS NIH HHS KL2 TR001870NCATS NIH HHS TL1 TR001871NIAID NIH HHS K24 AI144954NIA NIH HHS K23 AG048337NIA NIH HHS R01 AG059183NIDDK NIH HHS F32 DK124941NIDDK NIH HHS K24 DK101828NIDDK NIH HHS P30 DK026743NIDDK NIH HHS P30 DK132710
6 · The paper itself

Abstract

introductionLoneliness, "a subjective feeling of being isolated", is a strong predictor of adverse health. We characterized loneliness in patients with end-stage liver disease (ESLD) awaiting liver transplantation (LT).

methodsWe surveyed loneliness in ambulatory ESLD adults awaiting LT at 7 U.S. sites using the validated UCLA Three-Item Loneliness Scale, May2020-Jan2021; "lonely"=total ≥5. Liver Frailty Index (LFI) assessed frailty; "frail"=LFI≥4.4. Logistic regression associated loneliness and co-variables.

resultsOf 454 participants, median MELDNa was 14 (IQR 10-19) and 26% met criteria for "lonely". Compared to those not lonely, those lonely were younger (57 v. 61y), more likely to be female (48% v. 31%) or frail (21 v. 11%), and less likely to be working (15% v. 26%) or in a committed partnership (52% v. 71%). After multivariable adjustment, frailty (OR=2.24, 95%CI=1.23-4.08), younger age (OR=1.19, 95%CI=1.07-1.34), female sex (OR=1.83, 95%CI=1.14-2.92), not working (OR=2.16, 95%CI=1.16-4.03), and not in a committed partnership (OR=2.07, 95%CI=1.29-3.32) remained significantly associated with higher odds of loneliness.

conclusionLoneliness is prevalent in adults awaiting LT, and independently associated with younger age, female sex and physical frailty. These data lay the foundation to investigate the extent to which loneliness impacts health outcomes in LT, as in the general population. Clinical Trial Registry Website: https://clinicaltrials.gov Trial Number: NCT03228290.

Indexed as

End Stage Liver DiseaseFrailtyLiver TransplantationAdultFemaleHumansLonelinessMaleCirrhosisEnd-stage liver diseaseFrailtyMental healthPsychosocialQuality of lifeSocial isolationSocial support

Identifiers

PMID35460882
PMCPMC9533335
OpenAlexW4224226613

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.