Evidence map›Paper›PMID 35460410›Full record

Trial reportAge and ageing2022

Effect of an ongoing pharmacist service to reduce medicine-induced deterioration and adverse reactions in aged-care facilities (nursing homes): a multicentre, randomised controlled trial (the ReMInDAR trial).

Elizabeth E Roughead, Nicole L Pratt, Gaynor Parfitt, Debra Rowett, Lisa M Kalisch-Ellett, Luke Bereznicki, Tracy Merlin, Megan Corlis, Ai Choo Kang, Joseph Whitehouse and 10 more

Abstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Age and ageing, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 7 syntheses or guidelines pooled it.

  1. Pooled it
  2. Interventions for preventing falls in older people in care facilities.The Cochrane database of systematic reviews · 2025
    Pooled it
  3. Pooled it
  4. Pooled it
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  7. Pooled it
  8. Trial
  9. Article
  10. Article
  11. Review
  12. Innovations in pharmacovigilance studies of medicines in older people.British journal of clinical pharmacology · 2025
    Review
  13. Article
  14. Article
  15. Medication use quality and safety in older adults: 2022 update.Journal of the American Geriatrics Society · 2024
    Review
  16. Article
  17. Article
  18. [Polypharmacy in nursing homes: options to improve drug therapy safety].Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz · 2023
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Elizabeth E RougheadQuality Use of Medicines and Pharmacy Research Centre, UniSA Clinical and Health Sciences, University of South Australia, Adelaide, SA, Australia.
Nicole L PrattQuality Use of Medicines and Pharmacy Research Centre, UniSA Clinical and Health Sciences, University of South Australia, Adelaide, SA, Australia.
Gaynor ParfittAlliance for Research in Exercise, Nutrition and Activity, UniSA Allied Health & Human Performance, University of South Australia, Adelaide, SA, Australia.
Debra RowettQuality Use of Medicines and Pharmacy Research Centre, UniSA Clinical and Health Sciences, University of South Australia, Adelaide, SA, Australia.
Lisa M Kalisch-EllettQuality Use of Medicines and Pharmacy Research Centre, UniSA Clinical and Health Sciences, University of South Australia, Adelaide, SA, Australia.
Luke BereznickiSchool of Medicine, University of Tasmania, Tasmania, TAS, Australia.
Tracy MerlinAdelaide Health Technology Assessment, School of Public Health, University of Adelaide, Adelaide, SA, Australia.
Megan CorlisAustralian Nursing and Midwifery Federation (SA Branch), Ridleyton, SA, Australia.
Ai Choo KangUniversity of South Australia, Adelaide, SA, Australia.
Joseph WhitehousePharmacy Improvement Centre Ltd, Welland, SA, Australia.
Rebecca BiltonQuality Use of Medicines and Pharmacy Research Centre, UniSA Clinical and Health Sciences, University of South Australia, Adelaide, SA, Australia.
Camille SchubertAdelaide Health Technology Assessment, School of Public Health, University of Adelaide, Adelaide, SA, Australia.
Stacey TorodeUniversity of South Australia, Adelaide, SA, Australia.
Thu-Lan KellyQuality Use of Medicines and Pharmacy Research Centre, UniSA Clinical and Health Sciences, University of South Australia, Adelaide, SA, Australia.
Andre Q AndradeQuality Use of Medicines and Pharmacy Research Centre, UniSA Clinical and Health Sciences, University of South Australia, Adelaide, SA, Australia.ORCID 0000-0001-6587-3169
Dannielle PostAlliance for Research in Exercise, Nutrition and Activity, UniSA Allied Health & Human Performance, University of South Australia, Adelaide, SA, Australia.ORCID 0000-0002-8246-0363
Gereltuya DorjQuality Use of Medicines and Pharmacy Research Centre, UniSA Clinical and Health Sciences, University of South Australia, Adelaide, SA, Australia.
Justin CousinsSchool of Medicine, University of Tasmania, Tasmania, TAS, Australia.
Mackenzie WilliamsSchool of Medicine, University of Tasmania, Tasmania, TAS, Australia.
Renly LimQuality Use of Medicines and Pharmacy Research Centre, UniSA Clinical and Health Sciences, University of South Australia, Adelaide, SA, Australia.ORCID 0000-0003-4135-2523

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo assess the effectiveness of a pharmacist-led intervention using validated tools to reduce medicine-induced deterioration and adverse reactions. DESIGN AND

settingMulticenter, open-label parallel randomised controlled trial involving 39 Australian aged-care facilities.

participantsResidents on ≥4 medicines or ≥1 anticholinergic or sedative medicine.

interventionPharmacist-led intervention using validated tools to detect signs and symptoms of medicine-induced deterioration which occurred every 8 weeks over 12 months. COMPARATOR: Usual care (Residential Medication Management Review) provided by accredited pharmacists. OUTCOMES: Primary outcome was change in Frailty Index at 12 months. Secondary outcomes included changes in cognition, 24-hour movement behaviour by accelerometry, grip strength, weight, adverse events and quality of life.

results248 persons (median age 87 years) completed the study; 120 in the interventionand, 128 in control arms. In total 575 pharmacist, sessions were undertaken in the intervention arm. There was no statistically significant difference for change in frailty between groups (mean difference: 0.009, 95% CI: -0.028, 0.009, P = 0.320). A significant difference for cognition was observed, with a mean difference of 1.36 point change at 12 months (95% CI: 0.01, 2.72, P = 0.048). Changes in 24-hour movement behaviour, grip strength, adverse events and quality of life were not significantly different between groups. Point estimates favoured the intervention arm at 12 months for frailty, 24-hour movement behaviour and grip strength.

conclusionsThe use of validated tools by pharmacists to detect signs of medicine-induced deterioration is a model of practice that requires further research, with promising results from this trial, particularly with regards to improved cognition.

Indexed as

FrailtyPharmacistsAgedAged, 80 and overAustraliaCost-Benefit AnalysisHumansNursing HomesQuality of Lifeactivity trackercognitive functionhealth services researchmedication safetyolder peoplephysical activity

Identifiers

PMID35460410
PMCPMC9034696

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.