Evidence map›Paper›PMID 35460154›Full record

ReviewGenesis (New York, N.Y. : 2000)2022

Between a rock and a hard place: Regulation of mineralization in the periodontium.

Natalie L Andras, Fatma F Mohamed, Emily Y Chu, Brian L Foster

Abstract readReview
In one paragraph

Review in Genesis (New York, N.Y. : 2000), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. The role of bone sialoprotein in bone healing.Journal of structural biology · 2024
    Review
  6. The effectiveness ofHeliyon · 2024
    Article
  7. Dentoalveolar Alterations in an Adenine-Induced Chronic Kidney Disease Mouse Model.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2023
    Article
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Natalie L AndrasBiosciences Division, College of Dentistry, The Ohio State University, Columbus, Ohio, USA.
Fatma F MohamedBiosciences Division, College of Dentistry, The Ohio State University, Columbus, Ohio, USA.ORCID 0000-0003-1008-6541
Emily Y ChuDivision of Operative Dentistry, Department of General Dentistry, School of Dentistry, University of Maryland, Baltimore, Maryland, USA.
Brian L FosterBiosciences Division, College of Dentistry, The Ohio State University, Columbus, Ohio, USA.ORCID 0000-0003-3444-0576

Funding

Comprehensive Training in Oral &Craniofacial SciencesT32DE014320 · NIDCR · OHIO STATE UNIVERSITY · PI SHERIDAN, JOHN F · 2001 to 2022
$10.2M
Functions of extracellular matrix proteins in dental and skeletal mineralizationR01DE027639 · NIDCR · OHIO STATE UNIVERSITY · PI Brian Lee Foster · 2019 to 2026
$2.3M
Role of modulators of Pi/PPi in cementum formation and regenerationR00DE031148 · NIDCR · UNIVERSITY OF MARYLAND BALTIMORE · PI CHU, EMILY YIN · 2021 to 2023
$747k
Role of tissue-nonspecific alkaline phosphatase in dentoalveolar development and diseaseR03DE028411 · NIDCR · OHIO STATE UNIVERSITY · PI FOSTER, BRIAN LEE · 2019 to 2020
$312k
NIDCR NIH HHS R00 DE031148NIDCR NIH HHS R01 DE027639NIDCR NIH HHS R03 DE028411NIDCR NIH HHS T32 DE014320
6 · The paper itself

Abstract

The periodontium supports and attaches teeth via mineralized and nonmineralized tissues. It consists of two, unique mineralized tissues, cementum and alveolar bone. In between these tissues, lies an unmineralized, fibrous periodontal ligament (PDL), which distributes occlusal forces, nourishes and invests teeth, and harbors progenitor cells for dentoalveolar repair. Many unanswered questions remain regarding periodontal biology. This review will focus on recent research providing insights into one enduring mystery: the precise regulation of the hard-soft tissue borders in the periodontium which define the interfaces of the cementum-PDL-alveolar bone structure. We will focus on advances in understanding the molecular mechanisms that maintain the unmineralized PDL "between a rock and a hard place" by regulating the mineralization of cementum and alveolar bone.

Indexed as

Periodontal LigamentToothBone and BonesPeriodontiumStem Cellsalveolar bonecementumextracellular matrixmineralizationperiodontal

Identifiers

PMID35460154
PMCPMC9492628

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.