Evidence map›Paper›PMID 35460067›Full record

ReviewAnatomical science international2022

Formalin-free soft embalming of human cadavers using N-vinyl-2-pyrrolidone: perspectives for cadaver surgical training and medical device development.

Miki Nagase, Takashi Nagase, Joho Tokumine, Koichiro Saito, Eiji Sunami, Yoshiaki Shiokawa, George Matsumura

Abstract readReview
PubMed Publisher
In one paragraph

Review in Anatomical science international, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Miki NagaseDepartment of Anatomy, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka, Tokyo, 181-8611, Japan. mnagase@ks.kyorin-u.ac.jp.ORCID http://orcid.org/0000-0002-5741-578X
Takashi NagaseKunitachi Aoyagien Tachikawa Geriatric Health Services Facility, Tokyo, Japan.
Joho TokumineDepartment of Anesthesiology, Kyorin University School of Medicine, Tokyo, Japan.
Koichiro SaitoDepartment of Otolaryngology-Head and Neck Surgery, Kyorin University School of Medicine, Tokyo, Japan.
Eiji SunamiDepartment of Colorectal Surgery, Kyorin University School of Medicine, Tokyo, Japan.
Yoshiaki ShiokawaDepartment of Neurosurgery, Kyorin University School of Medicine, Tokyo, Japan.
George MatsumuraDepartment of Anatomy, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka, Tokyo, 181-8611, Japan.
Kyorin University · JPTachikawa Hospital · JP

Funding

Grants-in-Aid for Scientific Research from the Japan Society for the Promotion of Science 18K06841
6 · The paper itself

Abstract

The traditional apprenticeship approach to surgical skill education for young surgeons has drastically changed to more systematic surgical training using cadavers. Cadavers fixed with formalin are not suitable for surgical training because of their associated health hazards and overhardening. Recently, we established a formalin-free soft preservation method for human cadavers using N-vinyl-2-pyrrolidone. Since 2012, 61 cadavers have been embalmed with pyrrolidone in our institution. Tissues of pyrrolidone-embalmed cadavers are soft and pliable, and their bodies can be preserved for as long as 37 months without any signs of corruption. In this review, we introduce our recent attempts to apply pyrrolidone-embalmed cadavers in surgical and medical procedure training, including endotracheal intubation, motion physiology of the vocal folds, laparoscopic surgery, endoscopic skull base surgery, and development of novel medical devices. Future research perspectives on pyrrolidone embalming are discussed.

Indexed as

EmbalmingFormaldehydeCadaverHumansPyrrolidinones2-pyrrolidoneFormaldehydePyrrolidinonesCadaverEducationEmbalmingMedical deviceSurgical procedures, operative

Identifiers

PMID35460067
OpenAlexW4224219129

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.