Evidence map›Paper›PMID 35459850›Full record

ReviewNature reviews. Nephrology2022

Artificial intelligence-enabled decision support in nephrology.

Tyler J Loftus, Benjamin Shickel, Tezcan Ozrazgat-Baslanti, Yuanfang Ren, Benjamin S Glicksberg, Jie Cao, Karandeep Singh, Lili Chan, Girish N Nadkarni, Azra Bihorac

Open access · greenAbstract readReview
In one paragraph

Review in Nature reviews. Nephrology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed
4.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 88 citations in OpenAlex.

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  16. Contraceptive Use and Reproductive Health in Women With CKD: A Qualitative Study of Nephrologists in the United States.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Tyler J LoftusDepartment of Surgery, University of Florida Health, Gainesville, FL, USA.ORCID http://orcid.org/0000-0001-5354-443X
Benjamin ShickelDepartment of Medicine, University of Florida Health, Gainesville, FL, USA.
Tezcan Ozrazgat-BaslantiDepartment of Medicine, University of Florida Health, Gainesville, FL, USA.
Yuanfang RenDepartment of Medicine, University of Florida Health, Gainesville, FL, USA.ORCID http://orcid.org/0000-0002-4716-2408
Benjamin S GlicksbergDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0003-4515-8090
Jie CaoDepartment of Computational Medicine and Bioinformatics, University of Michigan Medical School, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0001-9803-3836
Karandeep SinghDepartment of Learning Health Sciences and Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA.
Lili ChanThe Mount Sinai Clinical Intelligence Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Girish N NadkarniThe Mount Sinai Clinical Intelligence Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Azra BihoracDepartment of Medicine, University of Florida Health, Gainesville, FL, USA. abihorac@ufl.edu.ORCID http://orcid.org/0000-0002-5745-2863
University of Florida Health · USIcahn School of Medicine at Mount Sinai · USUniversity of Michigan · US

Funding

Integrating data, algorithms and clinical reasoning for surgical risk assessmentR01GM110240 · NIGMS · UNIVERSITY OF FLORIDA · PI BIHORAC, AZRA, RASHIDI, PARISA · 2016 to 2025
$5.1M
SYSTEMATIC DRUG REPURPOSING TARGETING IMMUNE ACTIVATION NETWORKS IN ALZHEIMER'S DISEASE (AD)RF1AG059319 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI EHRLICH, MICHELLE E, GANDY, SAMUEL E. · 2018 to 2018
$4.2M
Integrated understanding of complex viral network biology in Alzheimer's DiseaseRF1AG058469 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI EHRLICH, MICHELLE E, GANDY, SAMUEL E. · 2019 to 2019
$4.1M
Elucidating Genetic and Environmental Second Hits in Racial and Ethnic Minorities with APOL1 High-Risk GenotypesR01DK127139 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI NADKARNI, GIRISH NITIN · 2021 to 2025
$4.0M
Elucidating hereditary transthyretin-mediated heart failure risk using machine learning, polygenic risk and recall by genotype approaches in African ancestry individualsR01HL155915 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI DO, RON, NADKARNI, GIRISH NITIN · 2021 to 2024
$3.4M
(MEnD-AKI) Multicenter Implementation of an Electronic Decision Support System for Drug-associated AKIR01DK121730 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BIHORAC, AZRA, KANE-GILL, SANDRA L · 2021 to 2025
$3.2M
ADAPT: Autonomous Delirium Monitoring and Adaptive PreventionR01NS120924 · NINDS · UNIVERSITY OF FLORIDA · PI BIHORAC, AZRA, RASHIDI, PARISA · 2021 to 2025
$2.9M
Intelligent Intensive Care Unit (I2CU): Pervasive Sensing and Artificial Intelligence for Augmented Clinical Decision-makingR01EB029699 · NIBIB · UNIVERSITY OF FLORIDA · PI BIHORAC, AZRA, RASHIDI, PARISA · 2021 to 2024
$2.4M
Integrating genomic and clinical data to predict disease phenotypes using heterogeneous ensemblesR01HG011407 · NHGRI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI SUAREZ-FARINAS, MAYTE · 2021 to 2024
$2.3M
3/4: Leveraging EHR-linked biobanks for deep phenotyping, polygenic risk score modeling, and outcomes analysis in psychiatric disordersR01MH121923 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI CHARNEY, ALEXANDER W · 2019 to 2023
$2.1M
COVID and Translational Science supercomputer (CATS)S10OD030463 · OD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KOVATCH, PATRICIA · 2021 to 2021
$2.0M
Big Omics Data Engine 2 SupercomputerS10OD026880 · OD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KOVATCH, PATRICIA · 2019 to 2019
$2.0M
NHGRI NIH HHS R01 HG011407NHLBI NIH HHS R01 HL155915NIA NIH HHS R56 AG058469NIA NIH HHS RF1 AG058469NIA NIH HHS RF1 AG059319NIBIB NIH HHS R01 EB029699NIBIB NIH HHS R21 EB027344NIDDK NIH HHS K01 DK120784NIDDK NIH HHS K23 DK124645NIDDK NIH HHS R01 DK121730NIDDK NIH HHS R01 DK123078NIDDK NIH HHS R01 DK127139NIGMS NIH HHS K23 GM140268NIGMS NIH HHS R01 GM110240NIH HHS S10 OD026880NIH HHS S10 OD030463NIMH NIH HHS R01 MH121923NINDS NIH HHS R01 NS120924
6 · The paper itself

Abstract

Kidney pathophysiology is often complex, nonlinear and heterogeneous, which limits the utility of hypothetical-deductive reasoning and linear, statistical approaches to diagnosis and treatment. Emerging evidence suggests that artificial intelligence (AI)-enabled decision support systems - which use algorithms based on learned examples - may have an important role in nephrology. Contemporary AI applications can accurately predict the onset of acute kidney injury before notable biochemical changes occur; can identify modifiable risk factors for chronic kidney disease onset and progression; can match or exceed human accuracy in recognizing renal tumours on imaging studies; and may augment prognostication and decision-making following renal transplantation. Future AI applications have the potential to make real-time, continuous recommendations for discrete actions and yield the greatest probability of achieving optimal kidney health outcomes. Realizing the clinical integration of AI applications will require cooperative, multidisciplinary commitment to ensure algorithm fairness, overcome barriers to clinical implementation, and build an AI-competent workforce. AI-enabled decision support should preserve the pre-eminence of wisdom and augment rather than replace human decision-making. By anchoring intuition with objective predictions and classifications, this approach should favour clinician intuition when it is honed by experience.

Indexed as

Decision Support Systems, ClinicalNephrologyAlgorithmsArtificial IntelligenceHumans

Identifiers

PMID35459850
PMCPMC9379375
OpenAlexW4224289643

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.