Evidence map›Paper›PMID 35459745›Full record

ArticleThorax2022

Ambient heat exposure and COPD hospitalisations in England: a nationwide case-crossover study during 2007-2018.

Garyfallos Konstantinoudis, Cosetta Minelli, Ana Maria Vicedo-Cabrera, Joan Ballester, Antonio Gasparrini, Marta Blangiardo

Abstract read
In one paragraph

Article in Thorax, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  3. Emergency Preparedness in Older Adults With and Without COPD During Power Outages and Natural Disasters.Journal of applied gerontology : the official journal of the Southern Gerontological Society · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Garyfallos KonstantinoudisMRC Centre for Environment and Health, Imperial College London, London, UK g.konstantinoudis@imperial.ac.uk.ORCID 0000-0001-7493-9334
Cosetta MinelliNHLI, Imperial College London National Heart and Lung Institute, London, UK.ORCID 0000-0001-9166-3958
Ana Maria Vicedo-CabreraInstitute of Social and Preventive Medicine, University of Bern, Bern, Switzerland.
Joan BallesterClimate and Health Program (CLIMA), Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain.
Antonio GasparriniDepartment of Public Health Environments and Society, London School of Hygiene & Tropical Medicine, London, UK.
Marta BlangiardoMRC Centre for Environment and Health, Imperial College London, London, UK.

Funding

Improving statistical methods for small area estimates of public health indicators and demographic characteristicsR01HD092580 · NICHD · EMORY UNIVERSITY · PI Lance A Waller · 2018 to 2026
$2.3M
Department of HealthMedical Research Council MR/L01341X/1Medical Research Council MR/R013349/1Medical Research Council MR/S019669/1Medical Research Council MR/T025352/1NICHD NIH HHS R01 HD092580
6 · The paper itself

Abstract

backgroundThere is emerging evidence suggesting a link between ambient heat exposure and chronic obstructive pulmonary disease (COPD) hospitalisations. Individual and contextual characteristics can affect population vulnerabilities to COPD hospitalisation due to heat exposure. This study quantifies the effect of ambient heat on COPD hospitalisations and examines population vulnerabilities by age, sex and contextual characteristics.

methodsIndividual data on COPD hospitalisation at high geographical resolution (postcodes) during 2007-2018 in England was retrieved from the small area health statistics unit. Maximum temperature at 1 km ×1 km resolution was available from the UK Met Office. We employed a case-crossover study design and fitted Bayesian conditional Poisson regression models. We adjusted for relative humidity and national holidays, and examined effect modification by age, sex, green space, average temperature, deprivation and urbanicity.

resultsAfter accounting for confounding, we found 1.47% (95% Credible Interval (CrI) 1.19% to 1.73%) increase in the hospitalisation risk for every 1°C increase in temperatures above 23.2°C (lags 0-2 days). We reported weak evidence of an effect modification by sex and age. We found a strong spatial determinant of the COPD hospitalisation risk due to heat exposure, which was alleviated when we accounted for contextual characteristics. 1851 (95% CrI 1 576 to 2 079) COPD hospitalisations were associated with temperatures above 23.2°C annually.

conclusionOur study suggests that resources should be allocated to support the public health systems, for instance, through developing or expanding heat-health alerts, to challenge the increasing future heat-related COPD hospitalisation burden.

Indexed as

Hot TemperaturePulmonary Disease, Chronic ObstructiveBayes TheoremCross-Over StudiesHospitalizationHumansCOPD epidemiologyCOPD ExacerbationsCOPD exacerbations mechanisms

Identifiers

PMID35459745
PMCPMC9606528

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.