ArticleVirology journal2022
A severe case of human rhinovirus A45 with central nervous system involvement and viral sepsis.
Article in Virology journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 12 citations in OpenAlex.
- A territory-wide study on adults hospitalized for rhinovirus infection - mortality, severe adverse respiratory and renal outcomes and relationships with multiple comorbidities.Journal of medical microbiology · 2026Article
- Full-length and near-full-length genomes of human rhinovirus A105 detected in patients with non-respiratory tract symptoms in Osaka, Japan.Microbiology resource announcements · 2025Article
- Clinical characteristics, outcomes, and subtype diversity in hospitalized human rhinovirus (HRV) patients.PloS one · 2025Article
- In silico molecular screening of bioactive natural compounds of rosemary essential oil and extracts for pharmacological potentials against rhinoviruses.Scientific reports · 2024Article
- Article
- Diagnostic challenges and forensic implications in a case of infantile fatal myocarditis.Forensic science, medicine, and pathology · 2024Article
- Fulminant myocarditis associated with human rhinovirus A66 infection: a case report.Frontiers in pediatrics · 2024Article
- Navigating paediatric virology through the COVID‑19 era (Review).International journal of molecular medicine · 2023Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRhinovirus is a common viral aetiology of upper respiratory infection and is mostly associated with common cold or flu-like illness. Although rhinovirus has been recognized as a pathogen for lower respiratory infections in severe cases credited to advances in molecular detection, central nervous system involvement and multiorgan dysfunction are extremely rare. CASE PRESENTATION: A previously healthy 10-year-old girl developed fever, sore throat and conjunctive injection after contact with an upper respiratory infection patient, followed by seizures, haematuria, and severe diarrhoea. She experienced viral sepsis and multiorgan dysfunction after admission. Cerebral computed tomography showed significant diffuse encephaledema. Cerebrospinal fluid analysis showed significantly elevated protein levels. After her consciousness disturbance improved, she still took a long time to recover from haematuria and diarrhoea. We identified a rarely reported rhinovirus A45 in her oropharyngeal and anal swabs by metagenomic next-generation sequencing, and bacterial culture of blood specimens yielded negative results.
conclusionsThis case presents a patient with severe rhinovirus infection, which was very likely responsible for her central nervous system symptoms and viral sepsis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.