Evidence map›Paper›PMID 35458726›Full record

ArticleMolecules (Basel, Switzerland)2022

Stereoselective Synthesis of β-Glycinamide Ribonucleotide.

Lisa Ngu, Debarpita Ray, Samantha S Watson, Penny J Beuning, Mary Jo Ondrechen, George A O'Doherty

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Lisa NguDepartment of Chemistry, Northeastern University, Boston, MA 02115, USA.
Debarpita RayDepartment of Chemistry, Northeastern University, Boston, MA 02115, USA.
Samantha S WatsonDepartment of Chemistry, Northeastern University, Boston, MA 02115, USA.
Penny J BeuningDepartment of Chemistry, Northeastern University, Boston, MA 02115, USA.
Mary Jo OndrechenDepartment of Chemistry, Northeastern University, Boston, MA 02115, USA.ORCID 0000-0003-2456-4313
George A O'DohertyDepartment of Chemistry, Northeastern University, Boston, MA 02115, USA.ORCID 0000-0002-1699-2249

Funding

De Novo Synthesis, and Functional and Structural Characterization of Novel Aminoglycoside Analogues to Bypass Resistance Mechanisms and Optimize SelectivityR01AI154860 · NIAID · BETH ISRAEL DEACONESS MEDICAL CENTER · PI KIRBY, JAMES E, O'DOHERTY, GEORGE A · 2020 to 2023
$3.1M
Apramycin scaffold exploration using novel glycochemistry and SAR studies to enhance activity against Acinetobacter baumannii and other multidrug-resistant Gram-negative pathogensR21AI142040 · NIAID · BETH ISRAEL DEACONESS MEDICAL CENTER · PI KIRBY, JAMES E, O'DOHERTY, GEORGE A · 2019 to 2020
$476k
National Science Foundation CHE-1905214National Science Foundation CHE-2102649National Science Foundation MCB-1517290NIH HHS AI142040NIH HHS AI154860
6 · The paper itself

Abstract

A diastereoselective synthesis of the β-anomer of glycinamide ribonucleotide (β-GAR) has been developed. The synthesis was accomplished in nine steps from D-ribose and occurred in 5% overall yield. The route provided material on the multi-milligram scale. The synthetic β-GAR formed was remarkably resistant to anomerization both in solution and as a solid.

Indexed as

Hydroxymethyl and Formyl TransferasesGlycinePhosphoribosylglycinamide FormyltransferaseRibonucleotidesglycinamide ribonucleotideGlycineHydroxymethyl and Formyl TransferasesPhosphoribosylglycinamide FormyltransferaseRibonucleotidesGARTstereoselective synthesisβ-GARβ-glycinamide ribonucleotide

Identifiers

PMID35458726
PMCPMC9024515

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.