Evidence map›Paper›PMID 35458649›Full record

ArticleMolecules (Basel, Switzerland)2022

Preclinical Pharmacokinetic Studies of a Novel Diuretic Inhibiting Urea Transporters.

Yue Xu, Hang Zhang, Nannan Li, Wen Ma, Shuyuan Wang, Jianguo Sun, Baoxue Yang

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Yue XuState Key Laboratory of Natural and Biomimetic Drugs, Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing 100191, China.ORCID 0000-0003-2755-4719
Hang ZhangState Key Laboratory of Natural and Biomimetic Drugs, Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing 100191, China.
Nannan LiState Key Laboratory of Natural and Biomimetic Drugs, Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing 100191, China.
Wen MaState Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.
Shuyuan WangState Key Laboratory of Natural and Biomimetic Drugs, Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing 100191, China.
Jianguo SunKey Lab of Drug Metabolism and Pharmacokinetics, State Key Laboratory of Natural Medicines, China Pharmaceutical University, 24 Tongjiaxiang Street, Nanjing 210009, China.ORCID 0000-0003-4417-7644
Baoxue YangState Key Laboratory of Natural and Biomimetic Drugs, Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing 100191, China.ORCID 0000-0002-7966-2095
Peking University · CNChina Pharmaceutical University · CN

Funding

National Natural Science Foundation of China 81620108029, 81974083, and 81330074
6 · The paper itself

Abstract

Urea transporter (UT) inhibitors are a class of promising novel diuretics that do not cause the imbalance of Na

Indexed as

DiureticsUreaAnimalsChromatography, LiquidMaleMembrane Transport ProteinsRatsRats, Sprague-DawleyUrea TransportersDiureticsMembrane Transport ProteinsUreaUrea TransportersdiureticsLC–MS/MSpharmacokineticstissue distributionurea transporter

Identifiers

PMID35458649
PMCPMC9027532
OpenAlexW4223603633

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.