Evidence map›Paper›PMID 35458637›Full record

ArticleMolecules (Basel, Switzerland)2022

Inhibition of Quorum-Sensing Regulator from

Yanxuan Xie, Jingxin Chen, Bo Wang, Ai-Yun Peng, Zong-Wan Mao, Wei Xia

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.

  1. Pooled it
  2. Antibacterial and anti-virulence effects ofMicrobiology spectrum · 2026
    Article
  3. Review
  4. Review
  5. Article
  6. Anti-QS Strategies AgainstMicroorganisms · 2025
    Review
  7. Article
  8. Article
  9. Article
  10. Anti-Biofilm Agents to OvercomePharmaceuticals (Basel, Switzerland) · 2025
    Review
  11. Theophylline as a quorum sensing and biofilm inhibitor in Pseudomonas aeruginosa and Chromobacterium violaceum.International microbiology : the official journal of the Spanish Society for Microbiology · 2024
    Article
  12. Review
  13. Article
  14. Article
  15. Peptide Extract from Red Kidney Beans,Biochemistry research international · 2024
    Article
  16. Review
  17. Flavonoid Synthesis byMicroorganisms · 2023
    Article
  18. Effect ofMolecules (Basel, Switzerland) · 2023
    Article
  19. The Molecular Architecture ofMarine drugs · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Yanxuan XieSchool of Chemistry, Sun Yat-Sen University, Guangzhou 510275, China.
Jingxin ChenSchool of Chemistry, Sun Yat-Sen University, Guangzhou 510275, China.ORCID 0000-0002-6613-5245
Bo WangSchool of Chemistry, Sun Yat-Sen University, Guangzhou 510275, China.
Ai-Yun PengSchool of Chemistry, Sun Yat-Sen University, Guangzhou 510275, China.
Zong-Wan MaoSchool of Chemistry, Sun Yat-Sen University, Guangzhou 510275, China.
Wei XiaSchool of Chemistry, Sun Yat-Sen University, Guangzhou 510275, China.ORCID 0000-0001-6480-3265
Sun Yat-sen University · CN

Funding

National Natural Science Foundation of China 21837006National Natural Science Foundation of China 21877131National Natural Science Foundation of China 22022706National Natural Science Foundation of China 22077142National Natural Science Foundation of China 91953117Natural Science Foundation of Guangdong Province, China 2019A1515011156
6 · The paper itself

Abstract

Quorum sensing (QS) is a cell-to-cell communication process that controls bacterial collective behaviors. The QS network regulates and coordinates bacterial virulence factor expression, antibiotic resistance and biofilm formation. Therefore, inhibition of the QS system is an effective strategy to suppress the bacterial virulence. Herein, we identify a phosphate ester derivative of chrysin as a potent QS inhibitor of the human pathogen

Indexed as

FlavonesQuorum SensingAnti-Bacterial AgentsBacterial ProteinsBiofilmsHumansPseudomonas aeruginosaVirulence FactorsAnti-Bacterial AgentsBacterial ProteinsflavoneFlavonesVirulence Factorsflavone derivativeinhibitorlas systemPseudomonas aeruginosaquorum sensing

Identifiers

PMID35458637
PMCPMC9031925
OpenAlexW4223558347

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.