Evidence map›Paper›PMID 35458620›Full record

ArticleMolecules (Basel, Switzerland)2022

Synthesis and Anti-Hepatitis B Activities of 3'-Fluoro-2'-Substituted Apionucleosides.

Martin Holan, Kathryn Tucker, Natalia Dyatkina, Hong Liu, April Kinkade, Guangyi Wang, Zhinan Jin, Marija Prhavc

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Martin HolanJanssen Research and Development, LLC, South San Francisco, CA 94080, USA.
Kathryn TuckerJanssen Research and Development, LLC, South San Francisco, CA 94080, USA.
Natalia DyatkinaJanssen Research and Development, LLC, South San Francisco, CA 94080, USA.ORCID 0000-0003-2330-7606
Hong LiuJanssen Research and Development, LLC, South San Francisco, CA 94080, USA.
April KinkadeJanssen Research and Development, LLC, South San Francisco, CA 94080, USA.
Guangyi WangJanssen Research and Development, LLC, South San Francisco, CA 94080, USA.
Zhinan JinJanssen Research and Development, LLC, South San Francisco, CA 94080, USA.
Marija PrhavcJanssen Research and Development, LLC, South San Francisco, CA 94080, USA.
Janssen (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nucleoside analogues have excellent records as anti-HBV drugs. Chronic infections require long-term administration ultimately leading to drug resistance. Therefore, the search for nucleosides with novel scaffolds is of high importance. Here we report the synthesis of novel 2'-hydroxy- and 2'-hydroxymethyl-apionucleosides,

Indexed as

Antiviral AgentsProdrugsHepatitis B virusNucleosidesAntiviral AgentsNucleosidesProdrugsapionucleosidesDNA-polymerase inhibitionHBV-antivirals

Identifiers

PMID35458620
PMCPMC9025269
OpenAlexW4224250937

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.