Evidence map›Paper›PMID 35458558›Full record

ArticleViruses2022

Investigations on SARS-CoV-2 Susceptibility of Domestic and Wild Animals Using Primary Cell Culture Models Derived from the Upper and Lower Respiratory Tract.

Iris Färber, Johannes Krüger, Cheila Rocha, Federico Armando, Maren von Köckritz-Blickwede, Stefan Pöhlmann, Armin Braun, Wolfgang Baumgärtner, Sandra Runft, Nadine Krüger

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Iris FärberDepartment of Pathology, University of Veterinary Medicine, Foundation, 30559 Hannover, Germany.ORCID 0000-0002-3390-5880
Johannes KrügerDepartment of Pathology, University of Veterinary Medicine, Foundation, 30559 Hannover, Germany.ORCID 0000-0002-4165-6271
Cheila RochaInfection Biology Unit, German Primate Center, Leibniz Institute for Primate Research, 37077 Göttingen, Germany.
Federico ArmandoDepartment of Pathology, University of Veterinary Medicine, Foundation, 30559 Hannover, Germany.ORCID 0000-0002-2578-4409
Maren von Köckritz-BlickwedeDepartment of Biochemistry, University of Veterinary Medicine Hannover, Foundation, 30559 Hannover, Germany.ORCID 0000-0001-7712-9767
Stefan PöhlmannInfection Biology Unit, German Primate Center, Leibniz Institute for Primate Research, 37077 Göttingen, Germany.ORCID 0000-0001-6086-9136
Armin BraunFraunhofer Institute for Toxicology and Experimental Medicine ITEM, 30625 Hannover, Germany.
Wolfgang BaumgärtnerDepartment of Pathology, University of Veterinary Medicine, Foundation, 30559 Hannover, Germany.ORCID 0000-0001-8151-5644
Sandra RunftDepartment of Pathology, University of Veterinary Medicine, Foundation, 30559 Hannover, Germany.ORCID 0000-0002-0879-5501
Nadine KrügerInfection Biology Unit, German Primate Center, Leibniz Institute for Primate Research, 37077 Göttingen, Germany.ORCID 0000-0002-4413-8699
University of Veterinary Medicine Hannover, Foundation · DEGerman Primate Center · DEFraunhofer Institute for Toxicology and Experimental Medicine · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Several animal species are susceptible to SARS-CoV-2 infection, as documented by case reports and serological and in vivo infection studies. However, the susceptibility of many animal species remains unknown. Furthermore, the expression patterns of SARS-CoV-2 entry factors, such as the receptor angiotensin-converting enzyme 2 (ACE2), as well as transmembrane protease serine subtype 2 (TMPRSS2) and cathepsin L (CTSL), cellular proteases involved in SARS-CoV-2 spike protein activation, are largely unexplored in most species. Here, we generated primary cell cultures from the respiratory tract of domestic and wildlife animals to assess their susceptibility to SARS-CoV-2 infection. Additionally, the presence of

Indexed as

COVID-19SARS-CoV-2Angiotensin-Converting Enzyme 2AnimalsAnimals, WildDogsFerretsHumansPrimary Cell CultureSpike Glycoprotein, CoronavirusAngiotensin-Converting Enzyme 2Spike Glycoprotein, Coronavirusspike protein, SARS-CoV-2ACE2air–liquid interfaceanimalsCTSLprimary cell culturesrespiratory tractSARS-CoV-2tissue explantsTMPRSS2zoonosis

Identifiers

PMID35458558
PMCPMC9032458
OpenAlexW4224289791

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.