Evidence map›Paper›PMID 35458514›Full record

ArticleViruses2022

An Approach to Quantifying the Interaction between Behavioral and Transmission Clusters.

Luisa Salazar-Vizcaya, Katharina Kusejko, Huldrych F Günthard, Jürg Böni, Karin J Metzner, Dominique L Braun, Dunja Nicca, Enos Bernasconi, Alexandra Calmy, Katharine E A Darling and 4 more

Abstract read
In one paragraph

Article in Viruses, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Luisa Salazar-VizcayaDepartment of Infectious Diseases, Bern University Hospital Inselspital, University of Bern, 3010 Bern, Switzerland.ORCID 0000-0003-0527-0141
Katharina KusejkoDepartment of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, 8091 Zurich, Switzerland.ORCID 0000-0002-4638-1940
Huldrych F GünthardDepartment of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, 8091 Zurich, Switzerland.ORCID 0000-0002-1142-6723
Jürg BöniInstitute of Medical Virology, University of Zurich, 8057 Zurich, Switzerland.ORCID 0000-0001-7925-4852
Karin J MetznerDepartment of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, 8091 Zurich, Switzerland.ORCID 0000-0003-4862-1503
Dominique L BraunDepartment of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, 8091 Zurich, Switzerland.ORCID 0000-0003-4036-1030
Dunja NiccaInstitute of Nursing Science, University of Basel, 4056 Basel, Switzerland.ORCID 0000-0002-4133-8177
Enos BernasconiDivision of Infectious Diseases, Ente Ospedaliero Cantonale, 6900 Lugano, Switzerland.
Alexandra CalmyDivision of Infectious Diseases, Geneva University Hospitals, 1205 Geneva, Switzerland.
Katharine E A DarlingInfectious Diseases Service, Lausanne University Hospital (CHUV), 1011 Lausanne, Switzerland.
Gilles WandelerDepartment of Infectious Diseases, Bern University Hospital Inselspital, University of Bern, 3010 Bern, Switzerland.
Roger D KouyosDepartment of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, 8091 Zurich, Switzerland.
Andri RauchDepartment of Infectious Diseases, Bern University Hospital Inselspital, University of Bern, 3010 Bern, Switzerland.
The Swiss Hiv Cohort Study

Funding

Swiss National Science Foundation 177499, 324730_179567
6 · The paper itself

Abstract

We hypothesize that patterns of sexual behavior play a role in the conformation of transmission networks, i.e., the way you behave might influence whom you have sex with. If that was the case, behavioral grouping might in turn correlate with, and potentially predict transmission networking, e.g., proximity in a viral phylogeny. We rigorously present an intuitive approach to address this hypothesis by quantifying mapped interactions between groups defined by similarities in sexual behavior along a virus phylogeny while discussing power and sample size considerations. Data from the Swiss HIV Cohort Study on condom use and hepatitis C virus (HCV) sequences served as proof-of-concept. In this case, a strict inclusion criteria contrasting with low HCV prevalence hindered our possibilities to identify significant relationships. This manuscript serves as guide for studies aimed at characterizing interactions between behavioral patterns and transmission networks. Large transmission networks such as those of HIV or COVID-19 are prime candidates for applying this methodological approach.

Indexed as

COVID-19Hepatitis CHIV InfectionsCohort StudiesHepacivirusHomosexuality, MaleHumansMalePhylogenyPrevalenceclustershepatitis C virussexual behaviortransmission networks

Identifiers

PMID35458514
PMCPMC9032082

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.