SynthesisViruses2022
Multisystem Inflammatory Syndrome in Neonates Born to Mothers with SARS-CoV-2 Infection (MIS-N) and in Neonates and Infants Younger Than 6 Months with Acquired COVID-19 (MIS-C): A Systematic Review.
Synthesis in Viruses, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 43 citations in OpenAlex.
- Multisystem inflammatory syndrome in children: an Umbrella review.Journal of anesthesia · 2024Pooled it
- Multisystem inflammatory syndrome in neonates (MIS-N): a systematic review.European journal of pediatrics · 2023Pooled it
- Maternal Coronavirus Disease 2019 Test Positivity and Neonatal Intensive Care Unit Outcomes for Infants Born Extremely Preterm.The Journal of pediatrics · 2026Article
- Article
- Off-Label Use of Anakinra in Inflammatory Conditions in Neonates and Infants Up to 3 Months of Age: A Case Series and a Review of the Literature.Paediatric drugs · 2025Review
- Article
- Clinical Characteristics and Outcomes of SARS-CoV-2 Infection in Neonates with Persistent Pulmonary Hypertension of the Newborn (PPHN): A Systematic Review.Children (Basel, Switzerland) · 2024Review
- Article
- VAERS Vasculitis Adverse Events Retrospective Study: Etiology Model of Immune Complexes Activating Fc Receptors in Kawasaki Disease and Multisystem Inflammatory Syndromes.Life (Basel, Switzerland) · 2024Article
- New insight into the intravenous immunoglobulin treatment in Multisystem Inflammatory Syndrome in children and adults.Italian journal of pediatrics · 2024Review
- Multisystem inflammatory syndrome in neonates (MIS-N): an updated systematic review.Frontiers in pediatrics · 2024Review
- T Lymphocyte Subset Counts and Interferon-Gamma Production in Adults and Children with COVID-19: A Narrative Review.Journal of personalized medicine · 2023Review
- Immunology of Multisystem Inflammatory Syndrome after COVID-19 in Children: A Review of the Current Evidence.International journal of molecular sciences · 2023Review
- Foetal Intrapartum Compromise at Term: Could COVID-19 Infection Be Involved? A Case Report.Medicina (Kaunas, Lithuania) · 2023Article
- COVID-19 in the Asia Pacific: Impact on climate change, allergic diseases and One Health.Asia Pacific allergy · 2023Review
- Functional consequences of SARS-CoV-2 infection in pregnant women, fetoplacental unit, and neonate.Biochimica et biophysica acta. Molecular basis of disease · 2023Review
- Case report: Fatal lung hyperinflammation in a preterm newborn with SARS-CoV-2 infection.Frontiers in pediatrics · 2023Article
- Maternal COVID-19 Vaccine May Reduce the Risk of MIS-C in Infants: A Narrative Review.Vaccines · 2022Review
- Perinatal/maternal-fetal-infant dermatologic manifestations of SARS-CoV-2. An Overview and Implications for diagnosis, treatment, and prognosis.Frontiers in pediatrics · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
(1) Introduction: There is an increasing literature describing neonates born to mothers with SARS-CoV-2 infection (MIS-N) and infants infected with SARS-CoV-2 who presented with a severe disease (MIS-C). (2) Methods: To investigate clinical features of multisystem inflammatory syndrome in neonates and infants under six months of age, we used a systematic search to retrieve all relevant publications in the field. We screened in PubMed, EMBASE and Scopus for data published until 10 October 2021. (3) Results: Forty-eight articles were considered, including 29 case reports, six case series and 13 cohort studies. Regarding clinical features, only 18.2% of MIS-N neonates presented with fever; differently from older children with MIS-C, in which gastrointestinal symptoms were the most common manifestation, we displayed that cardiovascular dysfunction and respiratory distress are the prevalent findings both in neonates with MIS-N and in neonates/infants with MIS-C. (4) Conclusions: We suggest that all infants with suspected inflammatory disease should undergo echocardiography, due to the possibility of myocardial dysfunction and damage to the coronary arteries observed both in neonates with MIS-N and in neonates/infants with MIS-C. Moreover, we also summarize how they were treated and provide a therapeutic algorithm to suggest best management of these fragile infants.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.