Evidence map›Paper›PMID 35458478›Full record

ReviewViruses2022

mRNA- and Adenovirus-Based Vaccines against SARS-CoV-2 in HIV-Positive People.

Anna Rosa Garbuglia, Claudia Minosse, Paola Del Porto

Open access · goldAbstract readReview
In one paragraph

Review in Viruses, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
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  4. Thromboembolic Events in the Era of COVID-19: A Detailed Narrative Review.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2025
    Review
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  6. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Anna Rosa GarbugliaLaboratory of Virology, "Lazzaro Spallanzani" National Institute for Infectious Diseases, IRCCS, 00149 Rome, Italy.ORCID 0000-0002-2687-8642
Claudia MinosseLaboratory of Virology, "Lazzaro Spallanzani" National Institute for Infectious Diseases, IRCCS, 00149 Rome, Italy.ORCID 0000-0001-7833-9539
Paola Del PortoDepartment of Biology and Biotechnology 'C. Darwin', Sapienza University, 00100 Rome, Italy.
Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani · ITSapienza University of Rome · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

About two years have passed since the identification of SARS-CoV-2 in China. The rapid spread of this virus all over the world and its high transmissibility and pathogenicity in humans have resulted in a global pandemic. The negative impact of COVID-19 on health, society and the economy at the global level has pushed researchers and pharmaceutical companies to develop effective vaccines to fight SARS-CoV-2. Thanks to this collaborative effort, the first COVID-19 vaccine was developed in less than a year. Since then, several COVID-19 vaccines have been validated for use by the World Health Organization. Among these, mRNA- (BNT162b2 and mRNA1273) and adenovirus-based (ChAdOx1) vaccines were developed through the use of novel technologies. While all three of these vaccines have shown effectiveness against the COVID-19 disease and their immunogenicity was characterized in clinical trials in the general population, data on their efficacy and immunogenicity in people living with HIV (PLWH) are limited. In this review, we provide a description of the characteristics of mRNA- and adenovirus-based vaccines and of the immune response elicited in the general population by vaccination. Then we describe the use of these vaccines and their efficacy and immunogenicity in people living with HIV and we conclude with a discussion regarding some open questions concerning the use of mRNA- and adenovirus-based COVID-19 vaccines in PLWH.

Indexed as

Adenoviridae InfectionsAdenovirus VaccinesCOVID-19HIV SeropositivityAdenoviridaeBNT162 VaccineCOVID-19 VaccinesHumansImmunogenicity, VaccineRNA, MessengerSARS-CoV-2VaccinationAdenovirus VaccinesBNT162 VaccineCOVID-19 VaccinesRNA, Messengeradenoviral vaccineHIV infectionimmune responsemRNA vaccineSARS-CoV-2

Identifiers

PMID35458478
PMCPMC9031858
OpenAlexW4224323595

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.