Evidence map›Paper›PMID 35458085›Full record

ReviewNanomaterials (Basel, Switzerland)2022

Static and Dynamic Biomaterial Engineering for Cell Modulation.

Hyung-Joon Park, Hyunsik Hong, Ramar Thangam, Min-Gyo Song, Ju-Eun Kim, Eun-Hae Jo, Yun-Jeong Jang, Won-Hyoung Choi, Min-Young Lee, Heemin Kang and 1 more

Abstract readReview
In one paragraph

Review in Nanomaterials (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Review
  2. Article
  3. Dynamic Fibrous Hydrogels for Stem Cell Homing and In Situ Bone Regeneration.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Applications of functionally-adapted hydrogels in tendon repair.Frontiers in bioengineering and biotechnology · 2023
    Review
  11. Dynamic and static biomechanical traits of cardiac fibrosis.Frontiers in bioengineering and biotechnology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Hyung-Joon ParkDepartment of Interdisciplinary Biomicrosystem Technology, College of Engineering, Korea University, Seoul 02841, Korea.ORCID 0000-0002-8803-500X
Hyunsik HongDepartment of Materials Science and Engineering, College of Engineering, Korea University, Seoul 02841, Korea.ORCID 0000-0003-0823-3119
Ramar ThangamDepartment of Materials Science and Engineering, College of Engineering, Korea University, Seoul 02841, Korea.ORCID 0000-0002-6209-7149
Min-Gyo SongDepartment of Biomedical Engineering, College of Health Science, Korea University, Seoul 02841, Korea.ORCID 0000-0002-1530-3480
Ju-Eun KimDepartment of Biomedical Engineering, College of Engineering, Korea University, Seoul 02841, Korea.
Eun-Hae JoDepartment of Biomedical Engineering, College of Engineering, Korea University, Seoul 02841, Korea.
Yun-Jeong JangDepartment of Biomedical Engineering, Armour College of Engineering, Illinois Institute of Technology, Chicago, IL 60616, USA.
Won-Hyoung ChoiDepartment of Biomedical Engineering, College of Health Science, Korea University, Seoul 02841, Korea.ORCID 0000-0002-0905-7172
Min-Young LeeDepartment of Biomedical Engineering, College of Health Science, Korea University, Seoul 02841, Korea.
Heemin KangDepartment of Interdisciplinary Biomicrosystem Technology, College of Engineering, Korea University, Seoul 02841, Korea.
Kyu-Back LeeDepartment of Interdisciplinary Biomicrosystem Technology, College of Engineering, Korea University, Seoul 02841, Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the biological microenvironment, cells are surrounded by an extracellular matrix (ECM), with which they dynamically interact during various biological processes. Specifically, the physical and chemical properties of the ECM work cooperatively to influence the behavior and fate of cells directly and indirectly, which invokes various physiological responses in the body. Hence, efficient strategies to modulate cellular responses for a specific purpose have become important for various scientific fields such as biology, pharmacy, and medicine. Among many approaches, the utilization of biomaterials has been studied the most because they can be meticulously engineered to mimic cellular modulatory behavior. For such careful engineering, studies on physical modulation (e.g., ECM topography, stiffness, and wettability) and chemical manipulation (e.g., composition and soluble and surface biosignals) have been actively conducted. At present, the scope of research is being shifted from static (considering only the initial environment and the effects of each element) to biomimetic dynamic (including the concepts of time and gradient) modulation in both physical and chemical manipulations. This review provides an overall perspective on how the static and dynamic biomaterials are actively engineered to modulate targeted cellular responses while highlighting the importance and advance from static modulation to biomimetic dynamic modulation for biomedical applications.

Indexed as

biomaterial engineeringbiomedical engineeringcell modulationdynamic modulationstatic modulation

Identifiers

PMID35458085
PMCPMC9028203

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.